EIF2AK4
| Description | eIF-2-alpha kinase GCN2 |
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Gene and Protein Information
| Gene ID | 440275 |
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| Uniprot Accession IDs | C9JEC4 Q69YL7 Q6DC97 Q96GN6 Q9H5K1 Q9NSQ3 Q9NSZ5 Q9UJ56 |
| Ensembl ID | ENSP00000263791 |
| Symbol | GCN2 KIAA1338 GCN2 PVOD2 |
| Family | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. |
| Sequence | MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 453321 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 9598 | VGNC:2490 | OMA, EggNOG |
| Mouse | 27103 | Eif2ak4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 10090 | MGI:1353427 | Inparanoid, OMA, EggNOG |
| Rat | 114859 | Eif2ak4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 10116 | RGD:1311439 | Inparanoid, OMA, EggNOG |
| Dog | 478257 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 9615 | VGNC:40259 | Inparanoid, OMA, EggNOG |
| Horse | 100071494 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 9796 | VGNC:17480 | Inparanoid, OMA, EggNOG |
| Cow | 513829 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 9913 | VGNC:28383 | Inparanoid, OMA, EggNOG |
| Opossum | 100031798 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 13616 | Inparanoid, EggNOG | |
| Platypus | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687] | 9258 | OMA, EggNOG | ||
| Chicken | 423285 | EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 9031 | CGNC:7318 | Inparanoid, OMA |
| Anole lizard | 100552145 | eif2ak4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | eif2ak4 | eukaryotic translation initiation factor 2 alpha kinase 4 [Source:Xenbase;Acc:XB-GENE-967321] | 8364 | OMA, EggNOG | ||
| C. elegans | 174953 | gcn-2 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2 | 6239 | Inparanoid, OMA | |
| Fruitfly | 43709 | Gcn2 | CG1609 gene product from transcript CG1609-RA | 7227 | FBgn0019990 | Inparanoid, EggNOG |
| S.cerevisiae | 851877 | GCN2 | serine/threonine-protein kinase GCN2 | 4932 | S000002691 | Inparanoid, OMA, EggNOG |
Protein Classes
PANTHER Classes
protein / non-receptor serine/threonine protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / transferase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / non-receptor serine/threonine protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / transferase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
DTO Classes
protein / Kinase / Protein kinase / Other group / PEK family / GCN2 subfamily / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / Kinase / Protein kinase / Other group / PEK family / GCN2 subfamily / Eukaryotic translation initiation factor 2-alpha kinase 4
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Disease Type | Mondoid |
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Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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