Protein or Target Summary
eIF-2-alpha kinase GCN2
| Gene ID | 440275 |
|---|---|
| uniprot | Q9P2K8 |
| Gene Name | EIF2AK4 |
| Ensernbl ID | ENSP00000263791 |
| Family | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. |
| Sequence | MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF Show more |
Gene and Protein Information
| Species | Gene ID | Gene Symbol | Gene Name | Uniprot |
|---|---|---|---|---|
| HUMAN | 440275 | EIF2AK4 | eIF-2-alpha kinase GCN2 | Q9P2K8 |
| MOUSE | 27103 | Eif2ak4 | eIF-2-alpha kinase GCN2 | Q9QZ05 |
| MOUSE | Eif2ak4 | eIF-2-alpha kinase GCN2 | A2AUM1 | |
| MOUSE | 27103 | Eif2ak4 | eIF-2-alpha kinase GCN2 | A2AUM0 |
| MOUSE | Eif2ak4 | eIF-2-alpha kinase GCN2 | A2AUL9 | |
| MOUSE | Eif2ak4 | eIF-2-alpha kinase GCN2 | A2AUM2 | |
| RAT | Eif2ak4 | eIF-2-alpha kinase GCN2 | D4A7V9 |
Protein Classes
PANTHER Classes
protein / non-receptor serine/threonine protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / transferase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / non-receptor serine/threonine protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / protein kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / transferase / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / kinase / Eukaryotic translation initiation factor 2-alpha kinase 4
DTO Classes
protein / Kinase / Protein kinase / Other group / PEK family / GCN2 subfamily / Eukaryotic translation initiation factor 2-alpha kinase 4
protein / Kinase / Protein kinase / Other group / PEK family / GCN2 subfamily / Eukaryotic translation initiation factor 2-alpha kinase 4
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Disease Type | Mondoid |
|---|
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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Source: DataSourcesLicenses.xlsx