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PRKCZ

DescriptionProtein kinase C zeta type

Gene and Protein Information

Gene ID5590
Uniprot Accession IDs A8K4N0 A8MU64 B7Z2J7 E9PCW2 Q15207 Q5SYT5 Q969S4
Ensembl ID ENSP00000367830
Symbol PKC2 PKC2 PKC-ZETA
FamilyBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Sequence
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque100430236LOC100430236protein kinase C zeta type-like9544Inparanoid, OMA, EggNOG
Mouse18762Prkczprotein kinase C, zeta10090MGI:97602Inparanoid, OMA
Rat25522Prkczprotein kinase C, zeta10116RGD:3399Inparanoid, OMA
Dog479577PRKCZprotein kinase C zeta9615VGNC:44985Inparanoid, OMA
Horse100064240PRKCZprotein kinase C zeta9796VGNC:21850Inparanoid, OMA
Cow286877PRKCZprotein kinase C zeta9913VGNC:33336Inparanoid, OMA
Chicken419399PRKCZprotein kinase C zeta9031CGNC:866Inparanoid, OMA
Xenopus100101769prkczprotein kinase C zeta8364XB-GENE-494709Inparanoid, OMA
Zebrafish555737prkczprotein kinase C, zeta7955ZDB-GENE-070511-1Inparanoid, OMA
C. elegans173914pkc-3Protein kinase C-like 36239Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    calcium-binding protein    /    non-receptor serine/threonine protein kinase    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    transfer/carrier protein    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    protein kinase    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    calmodulin    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    annexin    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    transferase    /    Protein kinase c zeta type
protein    /    calcium-binding protein    /    kinase    /    Protein kinase c zeta type
DTO Classes
protein    /    Kinase    /    Protein kinase    /    AGC group    /    PKC family    /    PKC iota subfamily    /    Protein kinase c zeta type

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Lallena, M J MJ, Diaz-Meco, M T MT, Bren, G G, Payá, C V CV and Moscat, J J. 1999-03 Activation of IkappaB kinase beta by protein kinase C isoforms. [PMID:10022904]
      2.Doornbos, R P RP and 5 more authors. 1999-03-26 Protein kinase Czeta is a negative regulator of protein kinase B activity. [PMID:10085094]
      3.Delhase, M M, Hayakawa, M M, Chen, Y Y and Karin, M M. 1999-04-09 Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. [PMID:10195894]
      4.Ziegler, W H WH and 7 more authors. 1999-05-20 Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. [PMID:10339425]
      5.Sanz, L L, Sanchez, P P, Lallena, M J MJ, Diaz-Meco, M T MT and Moscat, J J. 1999-06-01 The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. [PMID:10356400]
      6.Park, J J and 5 more authors. 1999-06-01 Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. [PMID:10357815]
      7.Lim, Y P YP, Low, B C BC, Lim, J J, Wong, E S ES and Guy, G R GR. 1999-07-02 Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. [PMID:10383403]
      8.Gong, J J and 5 more authors. 1999-09-03 Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. [PMID:10477520]
      9.Seibenhener, M L ML and 5 more authors. 1999-07 Identification of Src as a novel atypical protein kinase C-interacting protein. [PMID:10527887]
      10.Xiao, D M DM and 6 more authors. 2000-01 Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes. [PMID:10617144]