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PKM

DescriptionPyruvate kinase PKM

Gene and Protein Information

Gene ID5315
Uniprot Accession IDs A6NFK3 B2R5N8 B3KRY0 B4DFX8 B4DUU6 P14786 Q53GK4 Q96E76 Q9BWB5 Q9UCV6 Q9UPF2
Ensembl ID ENSP00000320171
Symbol OIP3 PK2 PK3 PKM2 PK3 TCB OIP3 PKM2 CTHBP THBP1 HEL-S-30
FamilyBelongs to the pyruvate kinase family.
Sequence
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp748700PKMpyruvate kinase M1/29598VGNC:49018OMA, EggNOG
Macaque697742PKMpyruvate kinase M1/29544Inparanoid, OMA, EggNOG
Mouse18746Pkmpyruvate kinase, muscle10090MGI:97591Inparanoid, OMA, EggNOG
Rat25630Pkmpyruvate kinase M1/210116RGD:3337Inparanoid, OMA, EggNOG
Dog403874PKMpyruvate kinase M1/29615Inparanoid, EggNOG
Horse100063687PKMpyruvate kinase M1/29796VGNC:51636Inparanoid, EggNOG
Pig100158154PKMpyruvate kinase, muscle9823Inparanoid, EggNOG
Chicken396456PKMpyruvate kinase, muscle9031CGNC:1412Inparanoid, OMA
Anole lizard100567220pkmpyruvate kinase M1/228377Inparanoid, OMA
Zebrafish335817pkmapyruvate kinase M1/2a7955ZDB-GENE-031201-4Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Kinase    /    Non-protein kinase    /    Other small molecule kinase    /    Pyruvate kinase pkm

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
PKM AntibodyHuman,Mouse,Rat
  • IF/ICC
  • IHC
  • WB
Out of Stock
Expand
PKM2 AntibodyHuman,Mouse,Rat
  • IF/ICC
  • IHC
  • WB
In stock
Expand

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adrenocortical adenoma134Expression AtlasMONDO:0003924
      adrenocortical carcinoma1427Expression AtlasMONDO:0006639
      astrocytoma3773Expression AtlasMONDO:0021636
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast carcinoma2011Expression AtlasMONDO:0004989
      dermatomyositis987Expression AtlasMONDO:0016367
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      ependymoma5607Expression AtlasMONDO:0021191
      glioblastoma5998Expression AtlasMONDO:0018177
      group 4 medulloblastoma7142Expression AtlasMONDO:0007959

      Bibliography

      1.Lowrie, D J DJ, Stickney, J T JT and Ip, W W. 2000-11 Properties of the nonhelical end domains of vimentin suggest a role in maintaining intermediate filament network structure. [PMID:11162730]
      2.Simpson, J C JC, Wellenreuther, R R, Poustka, A A, Pepperkok, R R and Wiemann, S S. 2000-09 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. [PMID:11256614]
      3.van Niel, G G and 6 more authors. 2001-08 Intestinal epithelial cells secrete exosome-like vesicles. [PMID:11487543]
      4.Mazurek, S S, Grimm, H H, Boschek, C B CB, Vaupel, P P and Eigenbrodt, E E. 2002-01 Pyruvate kinase type M2: a crossroad in the tumor metabolome. [PMID:11895152]
      5.Valentini, Giovanna G and 9 more authors. 2002-06-28 Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. [PMID:11960989]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Wubbolts, Richard R and 8 more authors. 2003-03-28 Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. [PMID:12519789]
      8.Yuryev, Anton A and Wennogle, Lawrence P LP. 2003-02 Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. [PMID:12620389]
      9.Gevaert, Kris K and 6 more authors. 2003-05 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. [PMID:12665801]
      10.Hardt, P D PD, Toepler, M M, Ngoumou, B B, Rupp, J J and Kloer, H U HU.Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls. [PMID:12820312]