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RPS6KA1

DescriptionRibosomal protein S6 kinase alpha-1

Gene and Protein Information

Gene ID6195
Uniprot Accession IDs A6NGG4 A8K9K7 B2RDY8 B7Z5J0 E9PRI4 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2 S6K-alpha-1
Ensembl ID ENSP00000435412
Symbol MAPKAPK1A RSK1 RSK HU-1 RSK1 p90Rsk MAPKAPK1A
FamilyBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Sequence
MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTTL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp456664RPS6KA1ribosomal protein S6 kinase A19598VGNC:11015OMA, EggNOG
Macaque714794RPS6KA1ribosomal protein S6 kinase A19544Inparanoid, OMA, EggNOG
Mouse20111Rps6ka1ribosomal protein S6 kinase polypeptide 110090MGI:104558Inparanoid, OMA, EggNOG
Rat81771Rps6ka1ribosomal protein S6 kinase A110116RGD:620675Inparanoid, OMA, EggNOG
Dog487353RPS6KA1ribosomal protein S6 kinase A19615VGNC:45738Inparanoid, OMA, EggNOG
Horse100057166RPS6KA1ribosomal protein S6 kinase A19796VGNC:22557Inparanoid, OMA
Cow533908RPS6KA1ribosomal protein S6 kinase A19913VGNC:34140Inparanoid, OMA
Pig100523972RPS6KA1ribosomal protein S6 kinase A19823Inparanoid, OMA, EggNOG
Opossum100016076RPS6KA1ribosomal protein S6 kinase A113616Inparanoid, OMA
Xenopus100144704rps6ka1ribosomal protein S6 kinase A18364XB-GENE-479496Inparanoid, OMA
Zebrafish777728rps6ka1ribosomal protein S6 kinase a, polypeptide 17955ZDB-GENE-060929-516Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    AGC group    /    RSK family    /    RSK subfamily    /    Ribosomal protein s6 kinase alpha-1

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      lung carcinoma2913Expression AtlasMONDO:0005138
      osteosarcoma7970Expression AtlasMONDO:0009807
      psoriasis6696Expression AtlasMONDO:0005083
      tuberculosis2482Expression AtlasMONDO:0018076
      Sezary Syndrome28CTDMONDO:0017844
      Sezary Syndrome28DisGeNETMONDO:0017844

      Bibliography

      1.Heidenreich, O O and 10 more authors. 1999-05-14 MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. [PMID:10318869]
      2.Richards, S A SA, Fu, J J, Romanelli, A A, Shimamura, A A and Blenis, J J. 1999 Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. [PMID:10469565]
      3.Jensen, C J CJ and 5 more authors. 1999-09-17 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. [PMID:10480933]
      4.Scheid, M P MP, Schubert, K M KM and Duronio, V V. 1999-10-22 Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. [PMID:10521512]
      5.Buck, M M, Poli, V V, van der Geer, P P, Chojkier, M M and Hunter, T T. 1999-12 Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. [PMID:10635333]
      6.Walker, K S KS, Watt, P W PW and Cohen, P P. 2000-01-21 Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo. [PMID:10648825]
      7.Wu, M M and 7 more authors. 2000-02-01 c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. [PMID:10673502]
      8.Shimamura, A A, Ballif, B A BA, Richards, S A SA and Blenis, J J. 2000-02-10 Rsk1 mediates a MEK-MAP kinase cell survival signal. [PMID:10679322]
      9.Gil, J J, Alcamí, J J and Esteban, M M. 2000-03-09 Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex. [PMID:10723127]
      10.Flück, M M, Booth, F W FW and Waxham, M N MN. 2000-04-13 Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. [PMID:10753652]