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MAPK8

DescriptionMitogen-activated protein kinase 8

Gene and Protein Information

Gene ID5599
Uniprot Accession IDs P45983 B5BTZ5 B7ZLV4 D3DX88 D3DX92 Q15709 Q15712 Q15713 Q308M2 MAP kinase 8
Ensembl ID ENSP00000378974
Symbol JNK1 PRKM8 SAPK1 SAPK1C JNK JNK1 PRKM8 SAPK1 JNK-46 JNK1A2 SAPK1c JNK21B1/2
FamilyBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Sequence
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp450445MAPK8mitogen-activated protein kinase 89598VGNC:14517OMA, EggNOG
Macaque711115MAPK8mitogen-activated protein kinase 89544Inparanoid, OMA, EggNOG
Rat116554Mapk8mitogen-activated protein kinase 810116RGD:621506Inparanoid, OMA
Dog477746MAPK8mitogen-activated protein kinase 89615VGNC:43001Inparanoid, OMA
Horse100051798MAPK8mitogen-activated protein kinase 89796VGNC:19962Inparanoid, OMA
Cow539941MAPK8mitogen-activated protein kinase 89913VGNC:31223OMA, EggNOG
Pig396610MAPK8mitogen-activated protein kinase 89823OMA, EggNOG
Chicken423778MAPK8mitogen-activated protein kinase 89031CGNC:4584Inparanoid, OMA
Anole lizard100561907mapk8mitogen-activated protein kinase 828377Inparanoid, OMA
Zebrafish562720mapk8amitogen-activated protein kinase 8a7955ZDB-GENE-080218-17Inparanoid, OMA
C. elegans177460jnk-1Stress-activated protein kinase jnk-16239OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    non-receptor serine/threonine protein kinase    /    Mitogen-activated protein kinase 8
protein    /    protein kinase    /    Mitogen-activated protein kinase 8
protein    /    transferase    /    Mitogen-activated protein kinase 8
protein    /    kinase    /    Mitogen-activated protein kinase 8
DTO Classes
protein    /    Kinase    /    Protein kinase    /    CMGC group    /    MAPK family    /    JNK subfamily    /    Mitogen-activated protein kinase 8

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      acute myeloid leukemia927Expression AtlasMONDO:0018874
      adult high grade glioma4998Expression AtlasMONDO:0100342
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast cancer3880Expression AtlasMONDO:0007254
      ependymoma5607Expression AtlasMONDO:0021191
      glioblastoma5998Expression AtlasMONDO:0018177
      group 4 medulloblastoma7142Expression AtlasMONDO:0007959
      intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
      osteosarcoma7970Expression AtlasMONDO:0009807

      Bibliography

      1.Tanoue, T T, Moriguchi, T T and Nishida, E E. 1999-07-09 Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. [PMID:10391943]
      2.Kawasaki, M M and 5 more authors. 1999-07-01 A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. [PMID:10393177]
      3.Jain, N N, Zhang, T T, Kee, W H WH, Li, W W and Cao, X X. 1999-08-20 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. [PMID:10446219]
      4.Koyano, S S and 5 more authors. 1999-09-03 A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. [PMID:10471813]
      5.Yasuda, J J, Whitmarsh, A J AJ, Cavanagh, J J, Sharma, M M and Davis, R J RJ. 1999-10 The JIP group of mitogen-activated protein kinase scaffold proteins. [PMID:10490659]
      6.Mischiati, C C and 6 more authors. 1999-09-10 Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells. [PMID:10509564]
      7.Lim, C P CP and Cao, X X. 1999-10-22 Serine phosphorylation and negative regulation of Stat3 by JNK. [PMID:10521505]
      8.Ito, M M and 9 more authors. 1999-11 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. [PMID:10523642]
      9.Noguchi, K K and 5 more authors. 1999-11-12 Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. [PMID:10551811]
      10.Yamamoto, K K, Ichijo, H H and Korsmeyer, S J SJ. 1999-12 BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. [PMID:10567572]