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NR3C2

DescriptionMineralocorticoid receptor

Gene and Protein Information

Gene ID4306
Uniprot Accession IDs B0ZBF5 B0ZBF7 Q2NKL1 Q96KQ8 Q96KQ9 MR
Ensembl ID ENSP00000350815
Symbol MCR MLR MR MCR MLR NR3C2VIT
FamilyBelongs to the nuclear hormone receptor family. NR3 subfamily.
Sequence
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp461533NR3C2nuclear receptor subfamily 3 group C member 29598VGNC:2971OMA, EggNOG
Macaque704789NR3C2nuclear receptor subfamily 3 group C member 29544Inparanoid, OMA, EggNOG
Mouse110784Nr3c2nuclear receptor subfamily 3, group C, member 210090MGI:99459Inparanoid, OMA, EggNOG
Rat25672Nr3c2nuclear receptor subfamily 3, group C, member 210116RGD:3094Inparanoid, OMA, EggNOG
Dog475461NR3C2nuclear receptor subfamily 3 group C member 29615VGNC:43953Inparanoid, OMA, EggNOG
Horse100062570NR3C2nuclear receptor subfamily 3 group C member 29796VGNC:20870Inparanoid, OMA, EggNOG
Cow537614NR3C2nuclear receptor subfamily 3 group C member 29913VGNC:32244Inparanoid, OMA, EggNOG
Opossum100018377NR3C2nuclear receptor subfamily 3 group C member 213616Inparanoid, OMA, EggNOG
Platypus100080085NR3C2nuclear receptor subfamily 3 group C member 29258Inparanoid, OMA, EggNOG
Chicken374131NR3C2nuclear receptor subfamily 3 group C member 29031CGNC:49053OMA, EggNOG
Anole lizard100566367nr3c2nuclear receptor subfamily 3 group C member 228377Inparanoid, OMA, EggNOG
Xenopus100487449nr3c2nuclear receptor subfamily 3 group C member 28364XB-GENE-483085Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    Mineralocorticoid receptor
protein    /    receptor    /    Mineralocorticoid receptor
protein    /    nucleic acid binding    /    Mineralocorticoid receptor
protein    /    C4 zinc finger nuclear receptor    /    Mineralocorticoid receptor
DTO Classes
protein    /    Nuclear receptor    /    3-Ketosteroid receptors    /    Mineralocorticoid receptor

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Halushka, M K MK and 8 more authors. 1999-07 Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. [PMID:10391210]
      2.Freeman, B C BC, Felts, S J SJ, Toft, D O DO and Yamamoto, K R KR. 2000-02-15 The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. [PMID:10691735]
      3.Hellal-Levy, C C, Fagart, J J, Souque, A A and Rafestin-Oblin, M E ME. 2000-04 Mechanistic aspects of mineralocorticoid receptor activation. [PMID:10760050]
      4.Geller, D S DS and 9 more authors. 2000-07-07 Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. [PMID:10884226]
      5.Hellal-Levy, C C and 5 more authors. 2000-08 Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor. [PMID:10935545]
      6.Watzka, M M and 5 more authors. 2000-08-25 Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus. [PMID:10936692]
      7.Tajima, T T and 8 more authors. 2000-12 A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1. [PMID:11134129]
      8.Savory, J G JG and 6 more authors. 2001-02 Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces. [PMID:11154266]
      9.Viemann, M M, Peter, M M, López-Siguero, J P JP, Simic-Schleicher, G G and Sippell, W G WG. 2001-05 Evidence for genetic heterogeneity of pseudohypoaldosteronism type 1: identification of a novel mutation in the human mineralocorticoid receptor in one sporadic case and no mutations in two autosomal dominant kindreds. [PMID:11344206]
      10.Odermatt, A A, Arnold, P P and Frey, F J FJ. 2001-07-27 The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2. [PMID:11350956]