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MLX

DescriptionMax-like protein X

Gene and Protein Information

Gene ID6945
Uniprot Accession IDs A8K2J3 B2RAV8 B2RD73 Q53XM6 Q96FL2 Q9H2V0 Q9H2V1 Q9H2V2 Q9NXN3
Ensembl ID ENSP00000246912
Symbol BHLHD13 TCFL4 TF4 MAD7 MXD7 TCFL4 bHLHd13
Sequence
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454691MLXMLX, MAX dimerization protein9598VGNC:9460OMA, EggNOG
Macaque710570MLXMLX, MAX dimerization protein9544Inparanoid, OMA, EggNOG
Mouse21428MlxMAX-like protein X10090MGI:108398Inparanoid, OMA, EggNOG
Rat360631MlxMLX, MAX dimerization protein10116RGD:1308590Inparanoid, OMA, EggNOG
Dog607668MLXMLX, MAX dimerization protein9615VGNC:43267Inparanoid, OMA, EggNOG
Horse100052692MLXMLX, MAX dimerization protein9796VGNC:20214Inparanoid, OMA, EggNOG
Cow508531MLXMLX, MAX dimerization protein9913VGNC:31508Inparanoid, OMA, EggNOG
Pig100519270MLXMLX, MAX dimerization protein9823OMA, EggNOG
Opossum100011055MLXMLX, MAX dimerization protein13616Inparanoid, OMA, EggNOG
Chicken420026MLXMLX, MAX dimerization protein9031CGNC:2323Inparanoid, OMA, EggNOG
Anole lizard100564594mlxMLX, MAX dimerization protein28377Inparanoid, OMA, EggNOG
Xenopus101732928mlxMLX, MAX dimerization protein8364XB-GENE-970062Inparanoid, OMA, EggNOG
Zebrafish554119mlxMLX, MAX dimerization protein7955ZDB-GENE-050522-316Inparanoid, OMA
C. elegans175184mxl-2MaX-Like6239Inparanoid, EggNOG
Fruitfly43293bigmaxCG3350 gene product from transcript CG3350-RA7227FBgn0039509Inparanoid, EggNOG

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Takayasu's arteritis38MonarchMONDO:0017991
      glioblastoma5998Expression AtlasMONDO:0018177
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      lung cancer4468Expression AtlasMONDO:0008903
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170
      psoriasis6696Expression AtlasMONDO:0005083
      arteritis, takayasu38eRAMMONDO:0017991
      Takayasu Arteritis38DisGeNETMONDO:0017991

      Bibliography

      1.Billin, A N AN, Eilers, A L AL, Queva, C C and Ayer, D E DE. 1999-12-17 Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. [PMID:10593926]
      2.Meroni, G G and 6 more authors. 2000-07-06 Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? [PMID:10918583]
      3.Billin, A N AN, Eilers, A L AL, Coulter, K L KL, Logan, J S JS and Ayer, D E DE. 2000-12 MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. [PMID:11073985]
      4.Cairo, S S, Merla, G G, Urbinati, F F, Ballabio, A A and Reymond, A A. 2001-03-15 WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. [PMID:11230181]
      5.Eilers, Alanna L AL, Sundwall, Eleanor E, Lin, Monica M, Sullivan, April A AA and Ayer, Donald E DE. 2002-12 A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. [PMID:12446771]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      8.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      9.Ma, Lin L, Tsatsos, Nikolas G NG and Towle, Howard C HC. 2005-03-25 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [PMID:15664996]
      10.Rual, Jean-François JF and 37 more authors. 2005-10-20 Towards a proteome-scale map of the human protein-protein interaction network. [PMID:16189514]