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MAPKAPK2

DescriptionMAP kinase-activated protein kinase 2

Gene and Protein Information

Gene ID9261
Uniprot Accession IDs Q5SY30 Q5SY41 Q8IYD6 MAPK-activated protein kinase 2
Ensembl ID ENSP00000356070
Symbol MK2 MK-2 MAPKAP-K2
FamilyBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Sequence
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp744091MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29598VGNC:8074OMA, EggNOG
Macaque695044MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29544Inparanoid, OMA, EggNOG
Mouse17164Mapkapk2MAP kinase-activated protein kinase 210090MGI:109298Inparanoid, OMA, EggNOG
Rat289014Mapkapk2mitogen-activated protein kinase-activated protein kinase 210116RGD:631362Inparanoid, OMA
Dog490263MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29615VGNC:43006Inparanoid, OMA, EggNOG
Horse100055510MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29796VGNC:19966Inparanoid, OMA, EggNOG
Cow788091MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29913VGNC:54449Inparanoid, OMA, EggNOG
Pig100521986MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29823OMA, EggNOG
PlatypusMAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:6887]9258OMA, EggNOG
Chicken419847MAPKAPK2mitogen-activated protein kinase-activated protein kinase 29031CGNC:580Inparanoid, OMA, EggNOG
Anole lizard100562891mapkapk2mitogen-activated protein kinase-activated protein kinase 228377Inparanoid, OMA, EggNOG
Xenopus550101mapkapk2mitogen-activated protein kinase-activated protein kinase 28364XB-GENE-5896875Inparanoid, OMA, EggNOG
Zebrafish327321mapkapk2amitogen-activated protein kinase-activated protein kinase 2a7955ZDB-GENE-030131-5532Inparanoid, OMA, EggNOG
C. elegans176914mak-2MAP kinase-activated protein kinase mak-26239Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    cytoskeletal protein    /    non-receptor serine/threonine protein kinase    /    Map kinase-activated protein kinase 2
protein    /    cytoskeletal protein    /    protein kinase    /    Map kinase-activated protein kinase 2
protein    /    cytoskeletal protein    /    transferase    /    Map kinase-activated protein kinase 2
protein    /    cytoskeletal protein    /    kinase    /    Map kinase-activated protein kinase 2
protein    /    cytoskeletal protein    /    non-motor microtubule binding protein    /    Map kinase-activated protein kinase 2
DTO Classes
protein    /    Kinase    /    Protein kinase    /    CAMK group    /    MAPKAPK family    /    MAPKAPK subfamily    /    Map kinase-activated protein kinase 2

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Heidenreich, O O and 10 more authors. 1999-05-14 MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. [PMID:10318869]
      2.Kotlyarov, A A and 6 more authors. 1999-06 MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. [PMID:10559880]
      3.Flück, M M, Booth, F W FW and Waxham, M N MN. 2000-04-13 Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. [PMID:10753652]
      4.Werz, O O, Klemm, J J, Samuelsson, B B and Rådmark, O O. 2000-05-09 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. [PMID:10779545]
      5.Neufeld, B B and 7 more authors. 2000-07-07 Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. [PMID:10781029]
      6.Rane, M J MJ and 7 more authors. 2001-02-02 p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. [PMID:11042204]
      7.Kleppe, R R, Toska, K K and Haavik, J J. 2001-05 Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association. [PMID:11359875]
      8.Lemke, L E LE and 5 more authors. 2001-08 Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart. [PMID:11448140]
      9.Sofroniew, M V MV, Howe, C L CL and Mobley, W C WC. 2001 Nerve growth factor signaling, neuroprotection, and neural repair. [PMID:11520933]
      10. and Janknecht, R R. 2001-11-09 Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. [PMID:11551945]