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LPL

DescriptionLipoprotein lipase

Gene and Protein Information

Gene ID4023
Uniprot Accession IDs P06858 B2R5T9 Q16282 Q16283 Q96FC4 LPL
Ensembl ID ENSP00000309757
Symbol LIPD LIPD HDLCQ11
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp464031LPLlipoprotein lipase9598VGNC:854OMA, EggNOG
Macaque712887LPLlipoprotein lipase9544OMA, EggNOG
Mouse16956Lpllipoprotein lipase10090MGI:96820Inparanoid, OMA, EggNOG
Rat24539Lpllipoprotein lipase10116RGD:3017Inparanoid, OMA, EggNOG
Dog403626LPLlipoprotein lipase9615VGNC:42754Inparanoid, OMA, EggNOG
Horse100055358LPLlipoprotein lipase9796VGNC:19740Inparanoid, OMA, EggNOG
Cow280843LPLlipoprotein lipase9913VGNC:30969Inparanoid, OMA, EggNOG
Opossum100033067LPLlipoprotein lipase13616Inparanoid, EggNOG
Platypus100077350LPLlipoprotein lipase9258Inparanoid, OMA, EggNOG
Chicken396219LPLlipoprotein lipase9031CGNC:11495Inparanoid, OMA, EggNOG
Anole lizard100556298lpllipoprotein lipase28377Inparanoid, OMA, EggNOG
Xenopuslpllipoprotein lipase [Source:Xenbase;Acc:XB-GENE-951545]8364OMA, EggNOG
Zebrafish30354lpllipoprotein lipase7955ZDB-GENE-990415-139OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    hydrolase    /    esterase    /    Lipoprotein lipase
protein    /    hydrolase    /    storage protein    /    Lipoprotein lipase
protein    /    hydrolase    /    lipase    /    Lipoprotein lipase
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Lipase    /    Lipoprotein lipase

Associated Recombinant Proteins

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NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant Lipoprotein lipase AntibodyHuman
  • WB
Out of Stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Nielsen, M S MS, Jacobsen, C C, Olivecrona, G G, Gliemann, J J and Petersen, C M CM. 1999-03-26 Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. [PMID:10085125]
      2.Cargill, M M and 17 more authors. 1999-07 Characterization of single-nucleotide polymorphisms in coding regions of human genes. [PMID:10391209]
      3.Evans, D D, Wendt, D D, Ahle, S S, Guerra, A A and Beisiegel, U U. 1998 Compound heterozygosity for a new (S259G) and a previously described (G188E) mutation in lipoprotein lipase (LpL) as a cause of chylomicronemia. Mutations in brief no. 183. Online. [PMID:10660334]
      4.MacPhee, C E CE, Hatters, D M DM, Sawyer, W H WH and Howlett, G J GJ. 2000-03-28 Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. [PMID:10727238]
      5.Klannemark, M M, Suurinkeroinen, L L, Orho-Melander, M M, Groop, L L and Taskinen, M R MR. 2000-08 Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus. [PMID:11073182]
      6.Hadjadj, S S and 8 more authors. 2000-12 Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genétique de la Nephropathie Diabétique Study Group. Données Epidémiologiques sur le Syndrome d'Insulino-Résistance Study Group. [PMID:11096142]
      7.Marçais, C C and 8 more authors. 2000-11 Severe hypertriglyceridaemia in Type II diabetes: involvement of apoC-III Sst-I polymorphism, LPL mutations and apo E3 deficiency. [PMID:11126401]
      8.Sass, C C, Herbeth, B B, Siest, G G and Visvikis, S S. 2000-12 Lipoprotein lipase (C/G)447 polymorphism and blood pressure in the Stanislas Cohort. [PMID:11132601]
      9.Arca, M M and 9 more authors. 2000-11 The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis. [PMID:11140837]
      10.Masana, L L and 7 more authors. 2001-02 Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. [PMID:11171287]