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PNLIP

DescriptionPancreatic triacylglycerol lipase

Gene and Protein Information

Gene ID5406
Uniprot Accession IDs P16233 Q5VSQ2 PL
Ensembl ID ENSP00000358223
Symbol PL PTL PNLIPD
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp739640PNLIPpancreatic lipase9598VGNC:7855OMA, EggNOG
Macaque706689PNLIPpancreatic lipase9544Inparanoid, OMA, EggNOG
Mouse69060Pnlippancreatic lipase10090MGI:97722Inparanoid, OMA, EggNOG
Rat25702Pnlippancreatic lipase10116RGD:3360Inparanoid, OMA, EggNOG
Horse100034202PNLIPpancreatic lipase9796Inparanoid, OMA
Cow515764PNLIPpancreatic lipase9913Inparanoid, OMA, EggNOG
Pig100157809PNLIPpancreatic lipase9823Inparanoid, OMA
Chicken423916PNLIPpancreatic lipase9031CGNC:52079OMA, EggNOG
Xenopus100486161LOC100486161pancreatic triacylglycerol lipase-like8364OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    hydrolase    /    esterase    /    Pancreatic triacylglycerol lipase
protein    /    hydrolase    /    storage protein    /    Pancreatic triacylglycerol lipase
protein    /    hydrolase    /    lipase    /    Pancreatic triacylglycerol lipase
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Lipase    /    Pancreatic triacylglycerol lipase

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.van Bennekum, A M AM, Fisher, E A EA, Blaner, W S WS and Harrison, E H EH. 2000-04-25 Hydrolysis of retinyl esters by pancreatic triglyceride lipase. [PMID:10769148]
      2.Crandall, W V WV and Lowe, M E ME. 2001-04-20 Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. [PMID:11278590]
      3.Hegele, R A RA and 5 more authors. 2001 Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. [PMID:11393534]
      4.Chahinian, H H, Sias, B B and Carrière, F F. 2000-07 The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains. [PMID:12369922]
      5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      6.Lessinger, Jean-Marc JM and 7 more authors. 2003-02 Preparation and characterization of reference materials for human pancreatic lipase: BCR 693 (from human pancreatic juice) and BCR 694 (recombinant). [PMID:12667003]
      7.Giller, T T, Buchwald, P P, Blum-Kaelin, D D and Hunziker, W W. 1992-08-15 Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. [PMID:1379598]
      8.Ramos, Paul P and 8 more authors. 2003-11-04 Time-resolved fluorescence allows selective monitoring of Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase. [PMID:14580194]
      9.van Tilbeurgh, H H, Sarda, L L, Verger, R R and Cambillau, C C. 1992-09-10 Structure of the pancreatic lipase-procolipase complex. [PMID:1522902]
      10.Grandval, Philippe P and 6 more authors. 2004 Critical evaluation of a specific ELISA and two enzymatic assays of pancreatic lipases in human sera. [PMID:15316225]