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| Description | Hepatic triacylglycerol lipase |
|---|
Gene and Protein Information
| Gene ID | 3990 |
|---|---|
| Uniprot Accession IDs | P11150 A2RUB4 A8K9B6 O43571 P78529 Q99465 HL |
| Ensembl ID | ENSP00000299022 |
| Symbol | HTGL HL HTGL LIPH HDLCQ12 |
| Family | Belongs to the AB hydrolase superfamily. Lipase family. |
| Sequence | MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 746925 | LIPC | lipase C, hepatic type | 9598 | VGNC:7536 | OMA, EggNOG |
| Macaque | 701116 | LIPC | lipase C, hepatic type | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 15450 | Lipc | lipase, hepatic | 10090 | MGI:96216 | Inparanoid, OMA, EggNOG |
| Rat | 24538 | Lipc | lipase C, hepatic type | 10116 | RGD:3009 | Inparanoid, OMA |
| Dog | 478320 | LIPC | lipase C, hepatic type | 9615 | VGNC:42694 | Inparanoid, OMA, EggNOG |
| Horse | 100068346 | LIPC | lipase C, hepatic type | 9796 | VGNC:19686 | Inparanoid, OMA, EggNOG |
| Cow | LIPC | lipase C, hepatic type [Source:HGNC Symbol;Acc:HGNC:6619] | 9913 | OMA, EggNOG | ||
| Pig | 100233189 | LIPC | lipase C, hepatic type | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100027348 | LIPC | lipase C, hepatic type | 13616 | Inparanoid, EggNOG | |
| Chicken | 427495 | LIPC | lipase C, hepatic type | 9031 | CGNC:3109 | Inparanoid, OMA |
| Anole lizard | 100556018 | lipc | lipase C, hepatic type | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 100135730 | lipc | lipase, hepatic type | 8364 | XB-GENE-955547 | Inparanoid, OMA, EggNOG |
| Zebrafish | 393997 | lipca | lipase, hepatic a | 7955 | ZDB-GENE-040426-1361 | Inparanoid, OMA, EggNOG |
Protein Classes
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|---|---|---|
| Hepatic lipase deficiency | 0 | UniProt Disease | |
| Hepatic lipase deficiency | 1 | Monarch | MONDO:0013533 |
| Diabetes Mellitus, Noninsulin-Dependent | 290 | Monarch | MONDO:0005148 |
| Hyperemia | 0 | Monarch | |
| atypical teratoid / rhabdoid tumor | 5491 | Expression Atlas | MONDO:0020560 |
| glioblastoma | 5998 | Expression Atlas | MONDO:0018177 |
| group 3 medulloblastoma | 7142 | Expression Atlas | MONDO:0007959 |
| medulloblastoma, large-cell | 6269 | Expression Atlas | MONDO:0002791 |
| pancreatic ductal adenocarcinoma liver metastasis | 3122 | Expression Atlas | MONDO:0005184 |
| primitive neuroectodermal tumor | 3050 | Expression Atlas | MONDO:0005462 |