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LIPG

DescriptionEndothelial lipase

Gene and Protein Information

Gene ID9388
Uniprot Accession IDs B0LPG6 Q6P9C8 Q6UW82
Ensembl ID ENSP00000261292
Symbol EL EDL PRO719
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp455413LIPGlipase G, endothelial type9598VGNC:7815OMA, EggNOG
Macaque699477LIPGlipase G, endothelial type9544Inparanoid, OMA, EggNOG
Mouse16891Lipglipase, endothelial10090MGI:1341803Inparanoid, EggNOG
Rat291437Lipglipase G, endothelial type10116RGD:1310740Inparanoid, EggNOG
Dog609249LIPGlipase G, endothelial type9615VGNC:53618Inparanoid, EggNOG
Horse100053762LIPGlipase G, endothelial type9796VGNC:50947Inparanoid, EggNOG
Pig100155736LIPGlipase G, endothelial type9823Inparanoid, EggNOG
Opossum100019990LIPGlipase G, endothelial type13616Inparanoid, EggNOG
Anole lizard100555250lipglipase G, endothelial type28377Inparanoid, OMA, EggNOG
Xenopus100498513lipglipase, endothelial8364XB-GENE-1011639Inparanoid, EggNOG
Zebrafish393096lipglipase, endothelial7955ZDB-GENE-040426-699Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    hydrolase    /    esterase    /    Endothelial lipase
protein    /    hydrolase    /    storage protein    /    Endothelial lipase
protein    /    hydrolase    /    lipase    /    Endothelial lipase
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Lipase    /    Endothelial lipase

Associated Approved Drugs

  1. orlistatTetrahydrouridine

    RETTchemnull

    pIC50: 8.22

Associated Active Ligands

  1. GSK-264220ATetrahydrouridine

    RETTchemnull

    IC50 p: 8.90

  2. US8987314, B88Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  3. US8987314, B379Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  4. US8987314, B226Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  5. US8987314, B64Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  6. US8987314, B309Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  7. US8987314, B193Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  8. US8987314, B227Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  9. US8987314, B87Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

  10. US8987314, B63Tetrahydrouridine

    RETTchemnull

    IC50 p: 9.30

Associated Diseases

NameDirect Associated TargetsDisease TypeMondoid
active Crohn's disease1059Expression AtlasMONDO:0005011
active ulcerative colitis2513Expression AtlasMONDO:0005101
adult high grade glioma4998Expression AtlasMONDO:0100342
Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
cystic fibrosis1831Expression AtlasMONDO:0009061
glioblastoma5998Expression AtlasMONDO:0018177
interstitial cystitis2307Expression AtlasMONDO:0018301
malignant mesothelioma3244Expression AtlasMONDO:0006292

Pathway

Data SourceNameExplore more targetsExplore in Source
KEGGGlycerolipid metabolism61 Targetspath:hsa00561
KEGGMetabolic pathways1433 Targetspath:hsa01100
KEGGCholesterol metabolism51 Targetspath:hsa04979