MAP3K8

DescriptionMitogen-activated protein kinase kinase kinase 8

Gene and Protein Information

Gene ID1326
Uniprot Accession IDs A8K2Q5 D3DRX1 Q14275 Q5T855 Q9HC81
Ensembl ID ENSP00000263056
Symbol COT ESTF COT EST ESTF TPL2 AURA2 MEKK8 Tpl-2 c-COT
FamilyBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Sequence
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp450384MAP3K8mitogen-activated protein kinase kinase kinase 89598VGNC:7238OMA, EggNOG
Macaque696936MAP3K8mitogen-activated protein kinase kinase kinase 89544OMA, EggNOG
Mouse26410Map3k8mitogen-activated protein kinase kinase kinase 810090MGI:1346878Inparanoid, OMA, EggNOG
Rat116596Map3k8mitogen-activated protein kinase kinase kinase 810116RGD:620969Inparanoid, OMA, EggNOG
Dog487085MAP3K8mitogen-activated protein kinase kinase kinase 89615VGNC:42979Inparanoid, OMA, EggNOG
Horse100063602MAP3K8mitogen-activated protein kinase kinase kinase 89796VGNC:19943Inparanoid, OMA, EggNOG
Cow535622MAP3K8mitogen-activated protein kinase kinase kinase 89913VGNC:31202Inparanoid, OMA, EggNOG
Pig100622217MAP3K8mitogen-activated protein kinase kinase kinase 89823OMA, EggNOG
Opossum100018684MAP3K8mitogen-activated protein kinase kinase kinase 813616Inparanoid, OMA, EggNOG
Platypus100076215MAP3K8mitogen-activated protein kinase kinase kinase 89258Inparanoid, OMA, EggNOG
Chicken420479MAP3K8mitogen-activated protein kinase kinase kinase 89031CGNC:5558Inparanoid, OMA, EggNOG
Anole lizard100562883map3k8mitogen-activated protein kinase kinase kinase 828377Inparanoid, OMA, EggNOG
Xenopus100493069map3k8mitogen-activated protein kinase kinase kinase 88364XB-GENE-958505Inparanoid, OMA, EggNOG
Zebrafish563727map3k8mitogen-activated protein kinase kinase kinase 87955ZDB-GENE-100316-8OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    STE group    /    STE-UNIQUE family    /    Mitogen-activated protein kinase kinase kinase 8

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDisease TypeMondoid

      Pathway

      Data SourceNameExplore more targetsExplore in Source