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DOT1L
| Description | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
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Gene and Protein Information
| Gene ID | 84444 |
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| Uniprot Accession IDs | O60379 Q96JL1 |
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| Ensembl ID | ENSP00000381657 |
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| Symbol | KIAA1814 KMT4 DOT1 KMT4 |
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| Family | Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. |
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| Sequence | MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 455566 | DOT1L | DOT1 like histone lysine methyltransferase | 9598 | VGNC:7478 | OMA, EggNOG |
| Macaque | 710033 | DOT1L | DOT1 like histone lysine methyltransferase | 9544 | | Inparanoid, OMA, EggNOG |
| Mouse | 208266 | Dot1l | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 10090 | MGI:2143886 | Inparanoid, OMA, EggNOG |
| Rat | 362831 | Dot1l | DOT1 like histone lysine methyltransferase | 10116 | RGD:1306644 | Inparanoid, OMA, EggNOG |
| Dog | 485073 | DOT1L | DOT1 like histone lysine methyltransferase | 9615 | VGNC:54298 | Inparanoid, OMA, EggNOG |
| Horse | 100068506 | DOT1L | DOT1 like histone lysine methyltransferase | 9796 | VGNC:50588 | Inparanoid, OMA, EggNOG |
| Cow | 510442 | DOT1L | DOT1 like histone lysine methyltransferase | 9913 | VGNC:50607 | OMA, EggNOG |
| Pig | 100738665 | DOT1L | DOT1 like histone lysine methyltransferase | 9823 | | OMA, EggNOG |
| Opossum | 100619840 | DOT1L | DOT1 like histone lysine methyltransferase | 13616 | | Inparanoid, OMA, EggNOG |
| Chicken | 420078 | DOT1L | DOT1 like histone lysine methyltransferase | 9031 | CGNC:549 | OMA, EggNOG |
| Xenopus | | dot1l | DOT1-like histone H3K79 methyltransferase [Source:Xenbase;Acc:XB-GENE-6033925] | 8364 | | OMA, EggNOG |
| Zebrafish | 559945 | dot1l | DOT1-like histone H3K79 methyltransferase | 7955 | ZDB-GENE-060503-341 | Inparanoid, OMA, EggNOG |
| Fruitfly | 40793 | gpp | grappa | 7227 | FBgn0264495 | Inparanoid, EggNOG |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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