Protein or Target Summary

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene ID	84444
uniprot	Q8TEK3
Gene Name	DOT1L
Ensernbl ID	ENSP00000381657
Family	Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Sequence	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN Show more

Gene and Protein Information

Species	Gene ID	Gene Symbol	Gene Name	Uniprot
HUMAN	84444	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Q8TEK3
MOUSE		Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	F6SJX8
MOUSE		Dot1l	Histone H3 methyltransferase DOT1 variant d	Q679P4
MOUSE		Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	F6S070
MOUSE		Dot1l	Histone H3 methyltransferase DOT1 variant a	Q6XZL7
MOUSE		Dot1l	Uncharacterized protein	Q3TMS8
MOUSE		Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	F7CVL0
MOUSE		Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Q679P5
MOUSE		Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Q5YL88
MOUSE		Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	E9Q6I8
MOUSE		Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	H9LAN6
MOUSE	208266	Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Q6XZL8
RAT	362831	Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific	D3ZCP0

Protein Classes

PANTHER Classes
protein / transferase / methyltransferase / Histone-lysine N-methyltransferase, H3 lysine-79 specific

DTO Classes
protein / Epigenetic regulator / Writer / Protein methyltransferase / Histone-lysine N-methyltransferase, H3 lysine-79 specific

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

Source: DataSourcesLicenses.xlsx