DOT1L

Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene and Protein Information

Gene ID	84444
Uniprot Accession IDs	O60379 Q96JL1
Ensembl ID	ENSP00000381657
Symbol	KIAA1814 KMT4 DOT1 KMT4
Family	Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Sequence	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	455566	DOT1L	DOT1 like histone lysine methyltransferase	9598	VGNC:7478	OMA, EggNOG
Macaque	710033	DOT1L	DOT1 like histone lysine methyltransferase	9544		Inparanoid, OMA, EggNOG
Mouse	208266	Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	10090	MGI:2143886	Inparanoid, OMA, EggNOG
Rat	362831	Dot1l	DOT1 like histone lysine methyltransferase	10116	RGD:1306644	Inparanoid, OMA, EggNOG
Dog	485073	DOT1L	DOT1 like histone lysine methyltransferase	9615	VGNC:54298	Inparanoid, OMA, EggNOG
Horse	100068506	DOT1L	DOT1 like histone lysine methyltransferase	9796	VGNC:50588	Inparanoid, OMA, EggNOG
Cow	510442	DOT1L	DOT1 like histone lysine methyltransferase	9913	VGNC:50607	OMA, EggNOG
Pig	100738665	DOT1L	DOT1 like histone lysine methyltransferase	9823		OMA, EggNOG
Opossum	100619840	DOT1L	DOT1 like histone lysine methyltransferase	13616		Inparanoid, OMA, EggNOG
Chicken	420078	DOT1L	DOT1 like histone lysine methyltransferase	9031	CGNC:549	OMA, EggNOG
Xenopus		dot1l	DOT1-like histone H3K79 methyltransferase [Source:Xenbase;Acc:XB-GENE-6033925]	8364		OMA, EggNOG
Zebrafish	559945	dot1l	DOT1-like histone H3K79 methyltransferase	7955	ZDB-GENE-060503-341	Inparanoid, OMA, EggNOG
Fruitfly	40793	gpp	grappa	7227	FBgn0264495	Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein / transferase / methyltransferase / Histone-lysine N-methyltransferase, H3 lysine-79 specific

DTO Classes
protein / Epigenetic regulator / Writer / Protein methyltransferase / Histone-lysine N-methyltransferase, H3 lysine-79 specific

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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