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Targets(Human)
MAP3K5

MAP3K5

Description	Mitogen-activated protein kinase kinase kinase 5

Gene and Protein Information

Gene ID	4217
Uniprot Accession IDs	A6NIA0 B4DGB2 Q5THN3 Q99461
Ensembl ID	ENSP00000351908
Symbol	ASK1 MAPKKK5 MEKK5 ASK1 MEKK5 MAPKKK5
Family	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Sequence	MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	463023	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9598	VGNC:10797	OMA, EggNOG
Macaque	711382	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9544		Inparanoid, OMA, EggNOG
Mouse	26408	Map3k5	mitogen-activated protein kinase kinase kinase 5	10090	MGI:1346876	Inparanoid, OMA, EggNOG
Rat	365057	Map3k5	mitogen-activated protein kinase kinase kinase 5	10116	RGD:1306565	Inparanoid, OMA, EggNOG
Dog	476215	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9615	VGNC:42975	Inparanoid, OMA
Horse	100073186	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9796	VGNC:19939	Inparanoid, OMA, EggNOG
Cow	537380	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9913	VGNC:31198	Inparanoid, OMA
Opossum	100031527	MAP3K5	mitogen-activated protein kinase kinase kinase 5	13616		OMA, EggNOG
Platypus	100081079	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9258		Inparanoid, OMA, EggNOG
Chicken	421688	MAP3K5	mitogen-activated protein kinase kinase kinase 5	9031	CGNC:10395	OMA, EggNOG
Anole lizard	100551616	map3k5	mitogen-activated protein kinase kinase kinase 5	28377		Inparanoid, OMA
Zebrafish	555703	map3k5	mitogen-activated protein kinase kinase kinase 5	7955	ZDB-GENE-030827-3	Inparanoid, OMA, EggNOG

Protein Classes

DTO Classes
protein / Kinase / Protein kinase / STE group / STE11 family / Mitogen-activated protein kinase kinase kinase 5

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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