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CA5B

DescriptionCarbonic anhydrase 5B, mitochondrial

Gene and Protein Information

Gene ID11238
Uniprot Accession IDs A8K4T5
Ensembl ID ENSP00000314099
Symbol CAVB CA-VB
FamilyBelongs to the alpha-carbonic anhydrase family.
Sequence
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque713128CA5Bcarbonic anhydrase 5B9544Inparanoid, OMA, EggNOG
Mouse56078Car5bcarbonic anhydrase 5b, mitochondrial10090MGI:1926249Inparanoid, OMA, EggNOG
Rat302669Car5bcarbonic anhydrase 5B10116RGD:1549783Inparanoid, OMA, EggNOG
Dog100856271CA5Bcarbonic anhydrase 5B9615VGNC:38613Inparanoid, OMA, EggNOG
Horse100051095LOC100051095carbonic anhydrase 5B, mitochondrial9796OMA, EggNOG
Cow514494CA5Bcarbonic anhydrase 5B9913VGNC:26655Inparanoid, OMA, EggNOG
Pig100156418CA5Bcarbonic anhydrase 5B9823OMA, EggNOG
Opossum100031763CA5Bcarbonic anhydrase 5B13616Inparanoid, OMA, EggNOG
PlatypusCA5Bcarbonic anhydrase 5B [Source:HGNC Symbol;Acc:HGNC:1378]9258OMA, EggNOG
Xenopus733981ca5bcarbonic anhydrase VB, mitochondrial8364XB-GENE-1003819Inparanoid, OMA

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      lung cancer4468Expression AtlasMONDO:0008903
      osteosarcoma7970Expression AtlasMONDO:0009807
      psoriasis6696Expression AtlasMONDO:0005083

      Bibliography

      1.Fujikawa-Adachi, K K, Nishimori, I I, Taguchi, T T and Onishi, S S. 1999-07-23 Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x. [PMID:10409679]
      2.Shah, G N GN and 6 more authors. 2000-02-15 Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. [PMID:10677517]
      3.Nishimori, I I and Onishi, S S.Carbonic anhydrase isozymes in the human pancreas. [PMID:11303978]
      4.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      5.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      6.Suzuki, Yutaka Y and 7 more authors. 2004-09 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. [PMID:15342556]
      7.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      8.Vullo, Daniela D, Nishimori, Isao I, Innocenti, Alessio A, Scozzafava, Andrea A and Supuran, Claudiu T CT. 2007-03-01 Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines. [PMID:17174092]
      9.Lamesch, Philippe P and 19 more authors. 2007-03 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. [PMID:17207965]
      10.Diez-Fernandez, Carmen C and 11 more authors. 2016-10 Defective hepatic bicarbonate production due to carbonic anhydrase VA deficiency leads to early-onset life-threatening metabolic crisis. [PMID:26913920]