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CTSB

DescriptionCathepsin B

Gene and Protein Information

Gene ID1508
Uniprot Accession IDs B3KQR5 B3KRR5 Q503A6 Q96D87
Ensembl ID ENSP00000345672
Symbol CPSB APPS CPSB RECEUP
FamilyBelongs to the peptidase C1 family.
Sequence
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463993CTSBcathepsin B9598VGNC:897OMA, EggNOG
Macaque100424758CTSBcathepsin B9544Inparanoid, OMA, EggNOG
Mouse13030Ctsbcathepsin B10090MGI:88561Inparanoid, OMA, EggNOG
Rat64529Ctsbcathepsin B10116RGD:621509Inparanoid, OMA, EggNOG
Dog486077CTSBcathepsin B9615VGNC:39709Inparanoid, OMA, EggNOG
Horse100060963CTSBcathepsin B9796VGNC:16948Inparanoid, OMA, EggNOG
Cow281105CTSBcathepsin B9913VGNC:27813Inparanoid, OMA, EggNOG
Pig100037961CTSBcathepsin B9823Inparanoid, OMA, EggNOG
Opossum100032681CTSBcathepsin B13616Inparanoid, EggNOG
Anole lizard100563878ctsbcathepsin B28377Inparanoid, OMA, EggNOG
Xenopus394833ctsbcathepsin B8364XB-GENE-1000505Inparanoid, OMA, EggNOG
Zebrafish406645ctsbacathepsin Ba7955ZDB-GENE-040426-2650Inparanoid, OMA, EggNOG
C. elegans179637cpr-1Gut-specific cysteine proteinase6239OMA, EggNOG
Fruitfly32341CtsB1Cathepsin B17227FBgn0030521Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    protease inhibitor    /    Cathepsin B
protein    /    cysteine protease    /    Cathepsin B
protein    /    protease    /    Cathepsin B
protein    /    hydrolase    /    Cathepsin B
DTO Classes
protein    /    Enzyme    /    Protease    /    Cysteine protease    /    Cathepsin B

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Mouse Cathepsin B ProteinHEK293C-10His
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Recombinant Human Cathepsin B ProteinHEK293C-His
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Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      acute quadriplegic myopathy1255Expression AtlasMONDO:0005336
      astrocytoma3773Expression AtlasMONDO:0021636
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast carcinoma2011Expression AtlasMONDO:0004989
      cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
      cystic fibrosis1831Expression AtlasMONDO:0009061
      Duchenne muscular dystrophy609Expression AtlasMONDO:0010679
      gastric carcinoma1287Expression AtlasMONDO:0004950
      glioblastoma5998Expression AtlasMONDO:0018177
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959

      Bibliography

      1.Estrada, S S, Pavlova, A A and Björk, I I. 1999-06-01 The contribution of N-terminal region residues of cystatin A (stefin A) to the affinity and kinetics of inhibition of papain, cathepsin B, and cathepsin L. [PMID:10353845]
      2.Söderström, M M and 5 more authors. 1999-07-07 Cathepsin expression during skeletal development. [PMID:10395917]
      3.Abts, H F HF and 5 more authors. 1999-10-15 Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. [PMID:10512713]
      4.Mai, J J, Finley, R L RL, Waisman, D M DM and Sloane, B F BF. 2000-04-28 Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. [PMID:10777578]
      5.Gerber, A A, Welte, T T, Ansorge, S S and Bühling, F F. 2000 Expression of cathepsins B and L in human lung epithelial cells is regulated by cytokines. [PMID:10849756]
      6.Tanaka, Y Y, Tanaka, R R, Kawabata, T T, Noguchi, Y Y and Himeno, M M. 2000-07 Lysosomal cysteine protease, cathepsin B, is targeted to lysosomes by the mannose 6-phosphate-independent pathway in rat hepatocytes: site-specific phosphorylation in oligosaccharides of the proregion. [PMID:10876156]
      7.Almeida, P C PC and 8 more authors. 2001-01-12 Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation. [PMID:11016923]
      8.Quraishi, O O and Storer, A C AC. 2001-03-16 Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family. [PMID:11115496]
      9.Jokimaa, V V, Oksjoki, S S, Kujari, H H, Vuorio, E E and Anttila, L L. 2001-01 Expression patterns of cathepsins B, H, K, L and S in the human endometrium. [PMID:11134363]
      10.Riccio, M M and 5 more authors. 2001-01-15 Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). [PMID:11139332]