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CACNA1C

DescriptionVoltage-dependent L-type calcium channel subunit alpha-1C

Gene and Protein Information

Gene ID775
Uniprot Accession IDs B2RUT3 E9PDJ0 Q13917 Q13918 Q13919 Q13920 Q13921 Q13922 Q13923 Q13924 Q13925 Q13926 Q13927 Q13928 Q13929 Q13930 Q13932 Q13933 Q14743 Q14744 Q15877 Q4VMI7 Q4VMI8 Q4VMI9 Q6PKM7 Q8N6C0 Q99025 Q99241 Q99875
Ensembl ID ENSP00000266376
Symbol CACH2 CACN2 CACNL1A1 CCHL1A1 TS LQT8 CACH2 CACN2 CaV1.2 CCHL1A1 CACNL1A1
FamilyBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Sequence
MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp466915CACNA1Ccalcium voltage-gated channel subunit alpha1 C9598VGNC:51248OMA, EggNOG
Macaque721721CACNA1Ccalcium voltage-gated channel subunit alpha1 C9544OMA, EggNOG
Mouse12288Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit10090MGI:103013Inparanoid, OMA, EggNOG
Rat24239Cacna1ccalcium voltage-gated channel subunit alpha1 C10116RGD:2245Inparanoid, OMA, EggNOG
Dog403516CACNA1Ccalcium voltage-gated channel subunit alpha1 C9615VGNC:38633Inparanoid, OMA, EggNOG
Horse100049924CACNA1Ccalcium voltage-gated channel subunit alpha1 C9796VGNC:15982Inparanoid, OMA, EggNOG
CowCACNA1Ccalcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]9913OMA, EggNOG
Anole lizard100553244cacna1ccalcium voltage-gated channel subunit alpha1 C28377Inparanoid, OMA
Zebrafish170581cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit7955ZDB-GENE-020129-1Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Ion channel    /    Calcium channel alpha-1 subunit family    /    CACNA1C subfamily    /    Voltage-dependent L-type calcium channel subunit alpha-1C

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Liu, W S WS, Soldatov, N M NM, Gustavsson, I I and Chowdhary, B P BP. 1998 Fiber-FISH analysis of the 3'-terminal region of the human L-type Ca2+ channel alpha 1C subunit gene. [PMID:10022083]
      2.Tanaka, H H, Furuya, T T, Kameda, N N, Kobayashi, T T and Mizusawa, H H. 2000 Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures. [PMID:11206130]
      3.Coppola, T T and 5 more authors. 2001-08-31 Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. [PMID:11438518]
      4.Waters, P J PJ, Scriver, C R CR and Parniak, M A MA. 2001-07 Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia. [PMID:11461190]
      5.Mouton, J J and 5 more authors. 2001-09-21 Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit. [PMID:11576544]
      6.Blumenstein, Yakov Y and 5 more authors. 2002-02-01 A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C. [PMID:11741969]
      7.Peng, Shuangqing S, Hajela, Ravindra K RK and Atchison, William D WD. 2002-08 Effects of methylmercury on human neuronal L-type calcium channels transiently expressed in human embryonic kidney cells (HEK-293). [PMID:12130699]
      8.Dai, Bosong B, Saada, Nehad N, Echetebu, Clement C, Dettbarn, Christine C and Palade, Philip P. 2002-08-16 A new promoter for alpha1C subunit of human L-type cardiac calcium channel Ca(V)1.2. [PMID:12163037]
      9.Iwasa, Hiroyasu H, Kurabayashi, Masahiko M, Nagai, Ryozo R, Nakamura, Yusuke Y and Tanaka, Toshihiro T. 2002 Twenty single-nucleotide polymorphisms in four genes encoding cardiac ion channels. [PMID:12166659]
      10.Lyford, Greg L GL and 9 more authors. 2002-09 alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation. [PMID:12176756]