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CA12

DescriptionCarbonic anhydrase 12

Gene and Protein Information

Gene ID771
Uniprot Accession IDs B2RE24 Q53YE5 Q9BWG2
Ensembl ID ENSP00000178638
Symbol CAXII CA-XII T18816 HsT18816
FamilyBelongs to the alpha-carbonic anhydrase family.
Sequence
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque705838CA12carbonic anhydrase 129544Inparanoid, OMA, EggNOG
Mouse76459Car12carbonic anhydrase 1210090MGI:1923709OMA, EggNOG
Rat363085Car12carbonic anhydrase 1210116RGD:1306612Inparanoid, OMA, EggNOG
Dog478333CA12carbonic anhydrase 129615VGNC:38607Inparanoid, OMA, EggNOG
Horse100054028CA12carbonic anhydrase 129796VGNC:15961Inparanoid, OMA, EggNOG
Cow614323CA12carbonic anhydrase 129913VGNC:26650Inparanoid, OMA, EggNOG
Pig100152749CA12carbonic anhydrase 129823OMA, EggNOG
Opossum100023076CA12carbonic anhydrase 1213616Inparanoid, EggNOG
PlatypusCA12carbonic anhydrase 12 [Source:HGNC Symbol;Acc:HGNC:1371]9258OMA, EggNOG
Chicken415370CA12carbonic anhydrase 129031CGNC:2518Inparanoid, OMA
Anole lizard100567887ca12carbonic anhydrase 1228377Inparanoid, OMA, EggNOG
Xenopus549185ca12carbonic anhydrase XII8364XB-GENE-1015246Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Fujikawa-Adachi, K K, Nishimori, I I, Taguchi, T T and Onishi, S S. 1999-10-01 Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. [PMID:10512682]
      2.Karhumaa, P P and 10 more authors. 2000-01 Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium. [PMID:10611263]
      3.Kivelä, A A and 11 more authors. 2000-02 Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors. [PMID:10666387]
      4.Kivelä, A J AJ and 10 more authors. 2000-09 Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. [PMID:11083462]
      5.Parkkila, S S and 10 more authors. 2000-12 Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors. [PMID:11101628]
      6.Wykoff, C C CC and 9 more authors. 2001-03 Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. [PMID:11238049]
      7.Karhumaa, P P and 7 more authors. 2001-07 Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts. [PMID:11420383]
      8.Whittington, D A DA and 6 more authors. 2001-08-14 Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. [PMID:11493685]
      9.Kivela, A J AJ and 10 more authors. 2001-10 Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. [PMID:11680594]
      10.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]