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CACNA1D

DescriptionVoltage-dependent L-type calcium channel subunit alpha-1D

Gene and Protein Information

Gene ID776
Uniprot Accession IDs B0FYA3 Q13916 Q13931 Q71UT1 Q9UDC3
Ensembl ID ENSP00000288139
Symbol CACH3 CACN4 CACNL1A2 CCHL1A2 CACH3 CACN4 PASNA SANDD Cav1.3 CCHL1A2 CACNL1A2
FamilyBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
Sequence
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp460447CACNA1Dcalcium voltage-gated channel subunit alpha1 D9598VGNC:53362OMA, EggNOG
Macaque693924CACNA1Dcalcium voltage-gated channel subunit alpha1 D9544OMA, EggNOG
Mouse12289Cacna1dcalcium channel, voltage-dependent, L type, alpha 1D subunit10090MGI:88293Inparanoid, OMA, EggNOG
Rat29716Cacna1dcalcium voltage-gated channel subunit alpha1 D10116RGD:70973Inparanoid, OMA, EggNOG
Dog484724CACNA1Dcalcium voltage-gated channel subunit alpha1 D9615VGNC:38634Inparanoid, OMA
Horse100051186CACNA1Dcalcium voltage-gated channel subunit alpha1 D9796VGNC:15983Inparanoid, OMA
Cow408013CACNA1Dcalcium voltage-gated channel subunit alpha1 D9913VGNC:26674Inparanoid, OMA
Opossum100014450CACNA1Dcalcium voltage-gated channel subunit alpha1 D13616Inparanoid, OMA
Zebrafish403310cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a7955ZDB-GENE-030616-135Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Ion channel    /    Calcium channel alpha-1 subunit family    /    CACNA1D subfamily    /    Voltage-dependent l-type calcium channel subunit alpha-1d

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Yang, S N SN and 9 more authors. 1999-08-31 Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. [PMID:10468580]
      2.Bell, D C DC and 9 more authors. 2001-02 Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. [PMID:11160515]
      3.Koschak, A A and 6 more authors. 2001-06-22 alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. [PMID:11285265]
      4.Rosenthal, R R, Thieme, H H and Strauss, O O. 2001-04 Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3). [PMID:11292657]
      5.Yamada, Y Y and 7 more authors.Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients. [PMID:11424233]
      6.Davare, M A MA and 8 more authors. 2001-07-06 A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. [PMID:11441182]
      7.Namkung, Y Y and 9 more authors. 2001-10 Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. [PMID:11581302]
      8.Williams, M E ME and 6 more authors. 1992-01 Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. [PMID:1309651]
      9.Seino, S S and 6 more authors. 1992-01-15 Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells. [PMID:1309948]
      10.Seino, S S, Yamada, Y Y, Espinosa, R R, Le Beau, M M MM and Bell, G I GI. 1992-08 Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3. [PMID:1324226]