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CACNA1S

DescriptionVoltage-dependent L-type calcium channel subunit alpha-1S

Gene and Protein Information

Gene ID779
Uniprot Accession IDs A4IF51 B1ALM2 Q12896 Q13934
Ensembl ID ENSP00000355192
Symbol CACH1 CACN1 CACNL1A3 MHS5 HOKPP TTPP1 Cav1.1 HOKPP1 hypoPP CCHL1A3 CACNL1A3
FamilyBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.
Sequence
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQHQGSQETLIPPRL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp469635CACNA1Scalcium voltage-gated channel subunit alpha1 S9598VGNC:11750Inparanoid, OMA, EggNOG
Mouse12292Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit10090MGI:88294Inparanoid, OMA, EggNOG
Rat682930Cacna1scalcium voltage-gated channel subunit alpha1 S10116RGD:70983OMA, EggNOG
Dog490244CACNA1Scalcium voltage-gated channel subunit alpha1 S9615VGNC:38640Inparanoid, OMA, EggNOG
Horse100034092CACNA1Scalcium voltage-gated channel subunit alpha1 S9796VGNC:15987Inparanoid, OMA, EggNOG
CowCACNA1Scalcium voltage-gated channel subunit alpha1 S [Source:HGNC Symbol;Acc:HGNC:1397]9913OMA, EggNOG
Pig100622149CACNA1Scalcium voltage-gated channel subunit alpha1 S9823OMA, EggNOG
Opossum100013684CACNA1Scalcium voltage-gated channel subunit alpha1 S13616Inparanoid, OMA, EggNOG
Anole lizard100551605cacna1scalcium voltage-gated channel subunit alpha1 S28377Inparanoid, OMA
Zebrafish405791cacna1sbcalcium channel, voltage-dependent, L type, alpha 1S subunit, b7955ZDB-GENE-051227-1Inparanoid, OMA
C. elegans177513egl-19Uncharacterized protein6239Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Ion channel    /    Calcium channel alpha-1 subunit family    /    CACNA1S subfamily    /    Voltage-dependent l-type calcium channel subunit alpha-1s

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Tanaka, H H, Furuya, T T, Kameda, N N, Kobayashi, T T and Mizusawa, H H. 2000 Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures. [PMID:11206130]
      2.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      3.Protasi, Feliciano F and 5 more authors. 2002-12 Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle. [PMID:12496092]
      4.Carsana, Antonella A, Fortunato, Giuliana G, De Sarno, Claudia C, Brancadoro, Virginia V and Salvatore, Francesco F. 2003-01 Identification of new polymorphisms in the CACNA1S gene. [PMID:12636044]
      5.Rotman, E I EI, De Jongh, K S KS, Florio, V V, Lai, Y Y and Catterall, W A WA. 1992-08-15 Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase. [PMID:1322891]
      6.Shibasaki, Tadao T, Sunaga, Yasuhiro Y, Fujimoto, Kei K, Kashima, Yasushige Y and Seino, Susumu S. 2004-02-27 Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. [PMID:14660679]
      7.Ng, W Y WY, Lui, K F KF, Thai, A C AC and Cheah, J S JS. 2004-03 Absence of ion channels CACN1AS and SCN4A mutations in thyrotoxic hypokalemic periodic paralysis. [PMID:15072700]
      8.Lin, Shih-Hua SH, Hsu, Yaw-Don YD, Cheng, Nai-Lin NL and Kao, Ming-Ching MC. 2005-02 Skeletal muscle dihydropyridine-sensitive calcium channel (CACNA1S) gene mutations in chinese patients with hypokalemic periodic paralysis. [PMID:15711422]
      9.Kim, June Bum JB, Lee, Kyung Yil KY and Hur, Jae Kyun JK. 2005-02 A Korean family of hypokalemic periodic paralysis with mutation in a voltage-gated calcium channel (R1239G). [PMID:15716625]
      10.Wang, Qiufen Q and 15 more authors. 2005-03 Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a Chinese family. [PMID:15726306]