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CA9

DescriptionCarbonic anhydrase 9

Gene and Protein Information

Gene ID768
Uniprot Accession IDs Q5T4R1
Ensembl ID ENSP00000367608
Symbol G250 MN MN CAIX
FamilyBelongs to the alpha-carbonic anhydrase family.
Sequence
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp473223CA9carbonic anhydrase 99598VGNC:9184OMA, EggNOG
Mouse230099Car9carbonic anhydrase 910090MGI:2447188Inparanoid, OMA, EggNOG
Rat313495Car9carbonic anhydrase 910116RGD:1306426Inparanoid, OMA, EggNOG
Dog611933CA9carbonic anhydrase 99615VGNC:38617Inparanoid, OMA, EggNOG
Horse100055579CA9carbonic anhydrase 99796VGNC:15968Inparanoid, OMA, EggNOG
Cow511923CA9carbonic anhydrase 99913VGNC:26659Inparanoid, OMA, EggNOG
Pig100152792CA9carbonic anhydrase 99823Inparanoid, OMA, EggNOG
Opossum100028099CA9carbonic anhydrase 913616Inparanoid, OMA, EggNOG
Chicken770004CA9carbonic anhydrase 99031CGNC:14529OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Human Carbonic Anhydrase IX Protein
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Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      active ulcerative colitis2513Expression AtlasMONDO:0005101
      colon cancer1587Expression AtlasMONDO:0021063
      intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286
      malignant mesothelioma3244Expression AtlasMONDO:0006292
      non-small cell lung cancer3141Expression AtlasMONDO:0005233
      pancreatic cancer2331Expression AtlasMONDO:0009831
      posterior fossa group A ependymoma5607Expression AtlasMONDO:0021191
      psoriasis6696Expression AtlasMONDO:0005083
      Anaplasia0CTD

      Bibliography

      1.Grabmaier, K K and 11 more authors. 2000-03-15 Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. [PMID:10709109]
      2.Kivelä, A J AJ and 10 more authors. 2000-09 Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. [PMID:11083462]
      3.Nishimori, I I and Onishi, S S.Carbonic anhydrase isozymes in the human pancreas. [PMID:11303978]
      4.Kivela, A J AJ and 10 more authors. 2001-10 Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. [PMID:11680594]
      5.Kaluz, Stefan S and 7 more authors. 2002-08-01 Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. [PMID:12154057]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Swinson, Daniel E B DE and 8 more authors. 2003-02-01 Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. [PMID:12560438]
      8.Bui, Matthew H T MH and 14 more authors. 2003-02 Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. [PMID:12576453]
      9.Kaluz, Stefan S, Kaluzová, Milota M and Stanbridge, Eric J EJ. 2003-03-01 Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. [PMID:12615703]
      10.Liao, S-Y SY and 8 more authors. 2003-04 Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. [PMID:12676895]