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CA7

DescriptionCarbonic anhydrase 7

Gene and Protein Information

Gene ID766
Uniprot Accession IDs Q541F0 Q86YU0
Ensembl ID ENSP00000345659
Symbol CAVII CA-VII
FamilyBelongs to the alpha-carbonic anhydrase family.
Sequence
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp740899CA7carbonic anhydrase 79598VGNC:9074OMA, EggNOG
Mouse12354Car7carbonic anhydrase 710090MGI:103100Inparanoid, OMA, EggNOG
Rat291819Car7carbonic anhydrase 710116RGD:1306842Inparanoid, OMA, EggNOG
Dog489772CA7carbonic anhydrase 79615VGNC:38615Inparanoid, OMA, EggNOG
Horse100065583CA7carbonic anhydrase 79796VGNC:51145Inparanoid, OMA, EggNOG
Cow520403CA7carbonic anhydrase 79913VGNC:26657Inparanoid, OMA, EggNOG
Opossum100014769CA7carbonic anhydrase 713616Inparanoid, EggNOG
PlatypusCA7carbonic anhydrase 7 [Source:HGNC Symbol;Acc:HGNC:1381]9258OMA, EggNOG
Xenopusca7carbonic anhydrase VII [Source:Xenbase;Acc:XB-GENE-1017206]8364OMA, EggNOG
Zebrafish564201ca7carbonic anhydrase VII7955ZDB-GENE-040426-1786Inparanoid, OMA, EggNOG

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      active Crohn's disease1059Expression AtlasMONDO:0005011
      ulcerative colitis2513Expression AtlasMONDO:0005101
      Angle-closure glaucoma0DrugCentral Indication
      Open-angle glaucoma0DrugCentral Indication
      Secondary glaucoma0DrugCentral Indication

      Bibliography

      1.Loftus, B J BJ and 18 more authors. 1999-09-15 Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. [PMID:10493829]
      2. and Breton, S S. 2001-07 The cellular physiology of carbonic anhydrases. [PMID:11875253]
      3.Chagnon, Pierre P and 8 more authors. 2002-12 A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. [PMID:12417987]
      4.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      5.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      6.Rivera, Claudio C, Voipio, Juha J and Kaila, Kai K. 2005-01-01 Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. [PMID:15528236]
      7.Vullo, Daniela D and 7 more authors. 2005-02-15 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. [PMID:15686895]
      8.Montgomery, J C JC and 5 more authors. 1991-12 Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. [PMID:1783392]
      9.Bootorabi, Fatemeh F and 10 more authors. 2010-08 Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme. [PMID:20493921]
      10.Orvedahl, Anthony A and 16 more authors. 2011-12-01 Image-based genome-wide siRNA screen identifies selective autophagy factors. [PMID:22020285]