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BIRC2

DescriptionBaculoviral IAP repeat-containing protein 2

Gene and Protein Information

Gene ID329
Uniprot Accession IDs B4E026 Q16516 Q4TTG0
Ensembl ID ENSP00000477613
Symbol API1 MIHB RNF48 API1 MIHB HIAP2 RNF48 cIAP1 Hiap-2 c-IAP1
FamilyBelongs to the IAP family.
Sequence
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp451508BIRC2baculoviral IAP repeat containing 29598VGNC:3201OMA, EggNOG
Macaque702592BIRC2baculoviral IAP repeat containing 29544Inparanoid, OMA, EggNOG
Mouse11797Birc2baculoviral IAP repeat-containing 210090MGI:1197009Inparanoid, OMA, EggNOG
Rat60371Birc2baculoviral IAP repeat-containing 210116RGD:620690Inparanoid, OMA, EggNOG
Dog479464BIRC2baculoviral IAP repeat containing 29615VGNC:38460Inparanoid, OMA
Horse100061273BIRC2baculoviral IAP repeat containing 29796VGNC:15832Inparanoid, OMA
PigBIRC3baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591]9823OMA, EggNOG
Opossum100010782LOC100010782baculoviral IAP repeat-containing protein 213616OMA, EggNOG
Platypus100077243BIRC2baculoviral IAP repeat containing 29258OMA, EggNOG
Chicken374012BIRC2baculoviral IAP repeat containing 29031CGNC:49004OMA, EggNOG
Anole lizard100554030birc2baculoviral IAP repeat containing 228377OMA, EggNOG
Xenopus448041birc2baculoviral IAP repeat containing 28364XB-GENE-966171OMA, EggNOG
Zebrafish373107birc2baculoviral IAP repeat containing 27955ZDB-GENE-030825-6OMA, EggNOG
Fruitfly36748Diap2Death-associated inhibitor of apoptosis 27227FBgn0015247OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    enzyme modulator    /    protease inhibitor    /    Baculoviral IAP repeat-containing protein 2
DTO Classes
protein    /    Enzyme modulator    /    Protease inhibitor    /    Baculoviral IAP repeat-containing protein 2

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant cIAP1 AntibodyHuman
  • IF/ICC
  • WB
In stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      dermatomyositis987Expression AtlasMONDO:0016367
      juvenile dermatomyositis1263Expression AtlasMONDO:0008054
      multiple myeloma1334Expression AtlasMONDO:0009693
      ovarian cancer8576Expression AtlasMONDO:0008170
      psoriasis6696Expression AtlasMONDO:0005083
      tuberculosis2482Expression AtlasMONDO:0018076
      Breast Neoplasms3880CTDMONDO:0007254
      Breast Neoplasms2011CTDMONDO:0004989
      HIV Infections150CTDMONDO:0005109
      Leukemia53CTDMONDO:0005059

      Bibliography

      1.Hinds, M G MG, Norton, R S RS, Vaux, D L DL and Day, C L CL. 1999-07 Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. [PMID:10404221]
      2.Yang, Y Y, Fang, S S, Jensen, J P JP, Weissman, A M AM and Ashwell, J D JD. 2000-05-05 Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. [PMID:10797013]
      3.Verhagen, A M AM and 8 more authors. 2000-07-07 Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. [PMID:10929712]
      4.Vucic, D D, Stennicke, H R HR, Pisabarro, M T MT, Salvesen, G S GS and Dixit, V M VM. 2000-11-02 ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. [PMID:11084335]
      5.Clem, R J RJ and 6 more authors. 2001-03-09 c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. [PMID:11106668]
      6.Werneburg, B G BG, Zoog, S J SJ, Dang, T T TT, Kehry, M R MR and Crute, J J JJ. 2001-11-16 Molecular characterization of CD40 signaling intermediates. [PMID:11562359]
      7.Suzuki, Y Y and 5 more authors. 2001-09 A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. [PMID:11583623]
      8.Verhagen, Anne M AM and 12 more authors. 2002-01-04 HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. [PMID:11604410]
      9.Mellström, Britt B and 5 more authors. 2002-03 Gas1 is induced during and participates in excitotoxic neuronal death. [PMID:11906213]
      10.Li, Xiaoming X, Yang, Yili Y and Ashwell, Jonathan D JD. 2002-03-21 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. [PMID:11907583]