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BIRC5

DescriptionBaculoviral IAP repeat-containing protein 5

Gene and Protein Information

Gene ID332
Uniprot Accession IDs A2SUH6 B2R4R1 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8
Ensembl ID ENSP00000301633
Symbol API4 IAP4 API4 EPR-1
FamilyBelongs to the IAP family.
Sequence
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp455276BIRC5baculoviral IAP repeat containing 59598VGNC:9133OMA, EggNOG
Macaque709565BIRC5baculoviral IAP repeat containing 59544Inparanoid, OMA
Mouse11799Birc5baculoviral IAP repeat-containing 510090MGI:1203517Inparanoid, OMA, EggNOG
Rat64041Birc5baculoviral IAP repeat-containing 510116RGD:70499Inparanoid, OMA, EggNOG
Dog442936BIRC5baculoviral IAP repeat containing 59615VGNC:38461Inparanoid, OMA, EggNOG
Horse100050808BIRC5baculoviral IAP repeat containing 59796Inparanoid, OMA, EggNOG
Cow414925BIRC5baculoviral IAP repeat containing 59913VGNC:26501Inparanoid, OMA, EggNOG
Opossum100031079BIRC5baculoviral IAP repeat containing 513616Inparanoid, OMA, EggNOG
Chicken374078BIRC5baculoviral IAP repeat containing 59031CGNC:6615Inparanoid, OMA, EggNOG
Anole lizard100566215birc5baculoviral IAP repeat containing 528377Inparanoid, EggNOG
Xenopus733575birc5.2baculoviral IAP repeat containing 58364XB-GENE-966741Inparanoid, OMA, EggNOG
Zebrafish373110birc5abaculoviral IAP repeat containing 5a7955ZDB-GENE-030826-1Inparanoid, EggNOG
Fruitfly42077DetDeterin7227FBgn0264291Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    protease inhibitor    /    Baculoviral IAP repeat-containing protein 5
DTO Classes
protein    /    Enzyme modulator    /    Protease inhibitor    /    Baculoviral IAP repeat-containing protein 5

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Human Survivin ProteinE. coliN-His
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Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adrenocortical carcinoma1427Expression AtlasMONDO:0006639
      adult high grade glioma4998Expression AtlasMONDO:0100342
      atopic dermatitis916Expression AtlasMONDO:0004980
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast cancer3880Expression AtlasMONDO:0007254
      breast carcinoma2011Expression AtlasMONDO:0004989
      colon cancer1587Expression AtlasMONDO:0021063
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      endometriosis473Expression AtlasMONDO:0005133
      ependymoma5607Expression AtlasMONDO:0021191

      Bibliography

      1.Mahotka, C C, Wenzel, M M, Springer, E E, Gabbert, H E HE and Gerharz, C D CD. 1999-12-15 Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. [PMID:10626797]
      2.Suzuki, A A and 9 more authors. 2000-03-02 Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. [PMID:10713676]
      3.Verdecia, M A MA and 5 more authors. 2000-07 Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. [PMID:10876248]
      4.Zaman, G J GJ and Conway, E M EM. 2000-07-01 The elusive factor Xa receptor: failure to detect transcripts that correspond to the published sequence of EPR-1. [PMID:10891443]
      5.Chantalat, L L and 5 more authors. 2000-07 Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. [PMID:10949039]
      6.Kasof, G M GM and Gomes, B C BC. 2001-02-02 Livin, a novel inhibitor of apoptosis protein family member. [PMID:11024045]
      7.O'Connor, D S DS and 8 more authors. 2000-11-21 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. [PMID:11069302]
      8.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      9.Uren, A G AG and 6 more authors. 2000-11-02 Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. [PMID:11084331]
      10.Skoufias, D A DA, Mollinari, C C, Lacroix, F B FB and Margolis, R L RL. 2000-12-25 Human survivin is a kinetochore-associated passenger protein. [PMID:11134084]