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BIRC3

DescriptionBaculoviral IAP repeat-containing protein 3

Gene and Protein Information

Gene ID330
Uniprot Accession IDs Q16628 Q9HC27 Q9UP46
Ensembl ID ENSP00000263464
Symbol API2 MIHC RNF49 AIP1 API2 MIHC CIAP2 HAIP1 HIAP1 IAP-1 MALT2 RNF49 c-IAP2
FamilyBelongs to the IAP family.
Sequence
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp451507BIRC3baculoviral IAP repeat containing 39598VGNC:11266OMA, EggNOG
Mouse11796Birc3baculoviral IAP repeat-containing 310090MGI:1197007Inparanoid, OMA, EggNOG
Rat78971Birc3baculoviral IAP repeat-containing 310116RGD:621282Inparanoid, OMA, EggNOG
Dog489433BIRC3baculoviral IAP repeat containing 39615VGNC:53305Inparanoid, OMA
Horse100068894BIRC3baculoviral IAP repeat containing 39796VGNC:15833Inparanoid, OMA
Cow514386BIRC3baculoviral IAP repeat containing 39913VGNC:26500Inparanoid, OMA
Xenopus448041birc2baculoviral IAP repeat containing 28364XB-GENE-966171Inparanoid, OMA
Zebrafish373107birc2baculoviral IAP repeat containing 27955ZDB-GENE-030825-6Inparanoid, OMA
Fruitfly36748Diap2Death-associated inhibitor of apoptosis 27227FBgn0015247Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    enzyme modulator    /    protease inhibitor    /    Baculoviral IAP repeat-containing protein 3
DTO Classes
protein    /    Enzyme modulator    /    Protease inhibitor    /    Baculoviral IAP repeat-containing protein 3

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      MALT lymphoma486MonarchMONDO:0007650
      active Crohn's disease1059Expression AtlasMONDO:0005011
      active ulcerative colitis2513Expression AtlasMONDO:0005101
      atopic dermatitis916Expression AtlasMONDO:0004980
      bipolar disorder535Expression AtlasMONDO:0004985
      cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
      cystic fibrosis1831Expression AtlasMONDO:0009061
      esophageal adenocarcinoma754Expression AtlasMONDO:0005028
      head and neck cancer501Expression AtlasMONDO:0005627
      interstitial cystitis2307Expression AtlasMONDO:0018301

      Bibliography

      1.Horrevoets, A J AJ and 5 more authors. 1999-05-15 Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. [PMID:10233894]
      2.Suzuki, H H, Motegi, M M, Akagi, T T, Hosokawa, Y Y and Seto, M M. 1999-11-01 API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) [PMID:10610122]
      3.Yang, Y Y, Fang, S S, Jensen, J P JP, Weissman, A M AM and Ashwell, J D JD. 2000-05-05 Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. [PMID:10797013]
      4.Verhagen, A M AM and 8 more authors. 2000-07-07 Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. [PMID:10929712]
      5.Baens, M M, Steyls, A A, Dierlamm, J J, De Wolf-Peeters, C C and Marynen, P P. 2000-12 Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. [PMID:11066071]
      6.Werneburg, B G BG, Zoog, S J SJ, Dang, T T TT, Kehry, M R MR and Crute, J J JJ. 2001-11-16 Molecular characterization of CD40 signaling intermediates. [PMID:11562359]
      7.Suzuki, Y Y and 5 more authors. 2001-09 A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. [PMID:11583623]
      8.Li, Xiaoming X, Yang, Yili Y and Ashwell, Jonathan D JD. 2002-03-21 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. [PMID:11907583]
      9.Bertoni, Francesco F, Cavalli, Franco F, Cotter, Finbarr E FE and Zucca, Emanuele E. 2002 Genetic alterations underlying the pathogenesis of MALT lymphoma. [PMID:11960389]
      10.Sharief, M K MK, Noori, M A MA and Zoukos, Y Y. 2002-08 Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy. [PMID:12161039]