BACE2

Description	Beta-secretase 2

Gene and Protein Information

Gene ID	25825
Uniprot Accession IDs	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6
Ensembl ID	ENSP00000332979
Symbol	AEPLC ALP56 ASP21 ASP1 BAE2 DRAP AEPLC ALP56 ASP21 CDA13 CEAP1
Family	Belongs to the peptidase A1 family.
Sequence	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	747819	BACE2	beta-site APP-cleaving enzyme 2	9598		OMA, EggNOG
Macaque	715330	BACE2	beta-site APP-cleaving enzyme 2	9544		Inparanoid, OMA, EggNOG
Mouse	56175	Bace2	beta-site APP-cleaving enzyme 2	10090	MGI:1860440	Inparanoid, OMA, EggNOG
Rat	288227	Bace2	beta-site APP-cleaving enzyme 2	10116	RGD:1303241	Inparanoid, OMA, EggNOG
Dog	478418	BACE2	beta-site APP-cleaving enzyme 2	9615	VGNC:38359	Inparanoid, OMA, EggNOG
Horse		BACE2	beta-site APP-cleaving enzyme 2 [Source:HGNC Symbol;Acc:HGNC:934]	9796		OMA, EggNOG
Cow	534774	BACE2	beta-site APP-cleaving enzyme 2	9913	VGNC:26401	Inparanoid, OMA, EggNOG
Pig	100517374	BACE2	beta-site APP-cleaving enzyme 2	9823		OMA, EggNOG
Opossum	100016587	BACE2	beta-site APP-cleaving enzyme 2	13616		Inparanoid, OMA, EggNOG
Platypus		BACE2	beta-site APP-cleaving enzyme 2 [Source:HGNC Symbol;Acc:HGNC:934]	9258		OMA, EggNOG
Anole lizard	100552914	bace2	beta-site APP-cleaving enzyme 2	28377		Inparanoid, OMA
Xenopus	100216145	bace2	beta-site APP-cleaving enzyme 2	8364	XB-GENE-1014090	Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    aspartic protease    /    Beta-secretase 2
protein    /    protease    /    Beta-secretase 2
protein    /    hydrolase    /    Beta-secretase 2

DTO Classes
protein / Enzyme / Protease / Aspartic protease / Beta-secretase 2

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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