Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

ACVR2A

DescriptionActivin receptor type-2A

Gene and Protein Information

Gene ID92
Uniprot Accession IDs B2RAB8 B4DWQ2 D3DP85 Q53TH4 Q6NWV2 Q92474
Ensembl ID ENSP00000241416
Symbol ACVR2 ACVR2 ACTRII
FamilyBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp459646ACVR2Aactivin A receptor type 2A9598VGNC:10526OMA, EggNOG
Macaque707017ACVR2Aactivin A receptor type 2A9544Inparanoid, OMA, EggNOG
Mouse11480Acvr2aactivin receptor IIA10090MGI:102806Inparanoid, OMA, EggNOG
Rat29263Acvr2aactivin A receptor type 2A10116RGD:70911Inparanoid, OMA, EggNOG
Dog476140ACVR2Aactivin A receptor type 2A9615VGNC:37564Inparanoid, OMA
Horse100049823ACVR2Aactivin A receptor type 2A9796VGNC:15038Inparanoid, OMA
Cow281598ACVR2Aactivin A receptor type 2A9913VGNC:25595Inparanoid, OMA
Opossum100018756ACVR2Aactivin A receptor type 2A13616Inparanoid, OMA
Chicken396324ACVR2Aactivin A receptor type 2A9031CGNC:9451Inparanoid, OMA
Anole lizard100562173acvr2aactivin A receptor type 2A28377Inparanoid, OMA
Xenopus100216172acvr2aactivin A receptor type 2A8364XB-GENE-484012Inparanoid, OMA
Zebrafish553359acvr2aaactivin A receptor type 2Aa7955ZDB-GENE-980526-227Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    receptor    /    protein kinase receptor    /    Activin receptor type-2a
protein    /    receptor    /    TGF-beta receptor    /    Activin receptor type-2a
protein    /    receptor    /    serine/threonine protein kinase receptor    /    Activin receptor type-2a
protein    /    receptor    /    protein kinase    /    Activin receptor type-2a
protein    /    receptor    /    transferase    /    Activin receptor type-2a
protein    /    receptor    /    kinase    /    Activin receptor type-2a
DTO Classes
protein    /    Kinase    /    Protein kinase    /    TKL group    /    STKR family    /    STKR Type 2 subfamily    /    Activin receptor type-2a

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant Activin Receptor Type IIA/ACVR2A AntibodyHuman,Mouse,Rat
  • WB
Out of Stock
Expand

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      acute myeloid leukemia927Expression AtlasMONDO:0018874
      adult high grade glioma4998Expression AtlasMONDO:0100342
      astrocytic glioma3773Expression AtlasMONDO:0021636
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast cancer3880Expression AtlasMONDO:0007254
      breast carcinoma2011Expression AtlasMONDO:0004989
      ependymoma5607Expression AtlasMONDO:0021191
      glioblastoma5998Expression AtlasMONDO:0018177
      interstitial cystitis2307Expression AtlasMONDO:0018301

      Bibliography

      1.Lux, A A, Attisano, L L and Marchuk, D A DA. 1999-04-09 Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. [PMID:10187774]
      2.D'Abronzo, F H FH, Swearingen, B B, Klibanski, A A and Alexander, J M JM. 1999-05 Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors. [PMID:10323406]
      3.Ebisawa, T T and 7 more authors. 1999-10 Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. [PMID:10504300]
      4.van Schaik, R H RH and 7 more authors. 2000-01 Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues. [PMID:10638976]
      5.Shoji, H H and 7 more authors. 2000-02-25 Identification and characterization of a PDZ protein that interacts with activin type II receptors. [PMID:10681527]
      6.Bondestam, J J, Horelli-Kuitunen, N N, Hildén, K K, Ritvos, O O and Aaltonen, J J. 1999 Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. [PMID:10702675]
      7.Lewis, K A KA and 6 more authors. 2000-03-23 Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. [PMID:10746731]
      8.Schulte, K M KM, Jonas, C C, Krebs, R R and Röher, H D HD. 2000-10 Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter? [PMID:11069203]
      9.Chapman, S C SC and Woodruff, T K TK. 2001-04 Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). [PMID:11266516]
      10.Matsuzaki, Takashi T and 7 more authors. 2002-05-24 Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. [PMID:11882656]