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| Description | High affinity copper uptake protein 1 |
|---|
Gene and Protein Information
| Gene ID | 1317 |
|---|---|
| Uniprot Accession IDs | O15431 A8K8Z6 Q53GR5 Q5T1M4 |
| Ensembl ID | ENSP00000363329 |
| Symbol | COPT1 CTR1 CTR1 COPT1 |
| Family | Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. |
| Sequence | MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 464670 | SLC31A1 | solute carrier family 31 member 1 | 9598 | VGNC:8934 | OMA, EggNOG |
| Macaque | 706058 | SLC31A1 | solute carrier family 31 member 1 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 20529 | Slc31a1 | solute carrier family 31, member 1 | 10090 | MGI:1333843 | Inparanoid, OMA, EggNOG |
| Rat | 171135 | Slc31a1 | solute carrier family 31 member 1 | 10116 | RGD:620059 | Inparanoid, OMA, EggNOG |
| Dog | 481678 | SLC31A1 | solute carrier family 31 member 1 | 9615 | VGNC:51761 | Inparanoid, OMA, EggNOG |
| Horse | 100050369 | SLC31A1 | solute carrier family 31 member 1 | 9796 | VGNC:23155 | Inparanoid, OMA, EggNOG |
| Cow | 518976 | SLC31A1 | solute carrier family 31 member 1 | 9913 | VGNC:34813 | Inparanoid, OMA, EggNOG |
| Opossum | SLC31A1 | solute carrier family 31 member 1 [Source:HGNC Symbol;Acc:HGNC:11016] | 13616 | Inparanoid, EggNOG | ||
| Platypus | SLC31A1 | solute carrier family 31 member 1 [Source:HGNC Symbol;Acc:HGNC:11016] | 9258 | OMA, EggNOG | ||
| Chicken | 417268 | SLC31A1 | solute carrier family 31 member 1 | 9031 | CGNC:6713 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100559623 | slc31a1 | solute carrier family 31 member 1 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 407919 | slc31a1 | solute carrier family 31 (copper transporter), member 1 | 8364 | XB-GENE-994882 | Inparanoid, OMA, EggNOG |
| Zebrafish | 403028 | slc31a1 | solute carrier family 31 (copper transporter), member 1 | 7955 | ZDB-GENE-040415-3 | Inparanoid, OMA, EggNOG |
| Fruitfly | 31601 | Ctr1A | Copper transporter 1A | 7227 | FBgn0062413 | Inparanoid, EggNOG |
Protein Classes
DTO Classes
protein / Transporter / SLC superfamily of solute carriers / SLC31 family of copper transporters / High affinity copper uptake protein 1
protein / Transporter / SLC superfamily of solute carriers / SLC31 family of copper transporters / High affinity copper uptake protein 1
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
|---|
Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
|---|---|---|---|---|---|
| Recombinant SLC31A1/CTR1 Antibody | Hamster,Human,Mouse,Rat |
In stock
| Expand⌵ |
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|
Bibliography
| 1.Møller, L B LB, Petersen, C C, Lund, C C and Horn, N N. 2000-10-17 Characterization of the hCTR1 gene: genomic organization, functional expression, and identification of a highly homologous processed gene. [PMID:11054564] |
| 2.Lee, Jaekwon J, Peña, Maria Marjorette O MM, Nose, Yasuhiro Y and Thiele, Dennis J DJ. 2002-02-08 Biochemical characterization of the human copper transporter Ctr1. [PMID:11734551] |
| 3.Puig, Sergi S, Lee, Jaekwon J, Lau, Miranda M and Thiele, Dennis J DJ. 2002-07-19 Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. [PMID:11983704] |
| 4.Eisses, John F JF and Kaplan, Jack H JH. 2002-08-09 Molecular characterization of hCTR1, the human copper uptake protein. [PMID:12034741] |
| 5.Lee, Jaekwon J, Petris, Michael J MJ and Thiele, Dennis J DJ. 2002-10-25 Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. [PMID:12177073] |
| 6.Klomp, Adriana E M AE and 5 more authors. 2003-03-15 The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. [PMID:12466020] |
| 7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932] |
| 8.Petris, Michael J MJ, Smith, Kathryn K, Lee, Jaekwon J and Thiele, Dennis J DJ. 2003-03-14 Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. [PMID:12501239] |
| 9.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039] |
| 10.Guo, Yan Y, Smith, Kathryn K, Lee, Jaekwon J, Thiele, Dennis J DJ and Petris, Michael J MJ. 2004-04-23 Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter. [PMID:14976198] |