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XIAP

DescriptionE3 ubiquitin-protein ligase XIAP

Gene and Protein Information

Gene ID331
Uniprot Accession IDs D3DTF2 Q9NQ14
Ensembl ID ENSP00000360242
Symbol API3 BIRC4 IAP3 API3 ILP1 MIHA XLP2 BIRC4 IAP-3 hIAP3 hIAP-3
FamilyBelongs to the IAP family.
Sequence
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp473765XIAPX-linked inhibitor of apoptosis9598VGNC:6437OMA, EggNOG
Mouse11798XiapX-linked inhibitor of apoptosis10090MGI:107572Inparanoid, OMA, EggNOG
Rat63879XiapX-linked inhibitor of apoptosis10116RGD:620692Inparanoid, OMA, EggNOG
Dog442989XIAPX-linked inhibitor of apoptosis9615OMA, EggNOG
Horse100060870XIAPX-linked inhibitor of apoptosis9796Inparanoid, OMA, EggNOG
Cow281647XIAPX-linked inhibitor of apoptosis9913Inparanoid, OMA, EggNOG
Pig100037300XIAPX-linked inhibitor of apoptosis9823Inparanoid, OMA, EggNOG
Opossum100016651XIAPX-linked inhibitor of apoptosis13616OMA, EggNOG
Anole lizard100557644xiapX-linked inhibitor of apoptosis28377OMA, EggNOG
Xenopus594971xiapX-linked inhibitor of apoptosis8364XB-GENE-948846Inparanoid, OMA, EggNOG
Zebrafish373108xiapX-linked inhibitor of apoptosis7955ZDB-GENE-030825-7OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    enzyme modulator    /    protease inhibitor    /    E3 ubiquitin-protein ligase XIAP
DTO Classes
protein    /    Enzyme modulator    /    Protease inhibitor    /    E3 ubiquitin-protein ligase XIAP

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Verhagen, A M AM and 8 more authors. 2000-07-07 Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. [PMID:10929712]
      2.Liu, Z Z and 8 more authors. 2000 Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. [PMID:11140637]
      3.Wu, G G and 6 more authors. 2000 Structural basis of IAP recognition by Smac/DIABLO. [PMID:11140638]
      4.Srinivasula, S M SM and 10 more authors. 2001-03-01 A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. [PMID:11242052]
      5.Chai, J J and 7 more authors. 2001-03-09 Structural basis of caspase-7 inhibition by XIAP. [PMID:11257230]
      6.Huang, Y Y and 5 more authors. 2001-03-09 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. [PMID:11257231]
      7.Riedl, S J SJ and 7 more authors. 2001-03-09 Structural basis for the inhibition of caspase-3 by XIAP. [PMID:11257232]
      8.Suzuki, Y Y, Nakabayashi, Y Y, Nakata, K K, Reed, J C JC and Takahashi, R R. 2001-07-20 X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. [PMID:11359776]
      9.Keane, R W RW and 6 more authors. 2001-05 Apoptotic and anti-apoptotic mechanisms following spinal cord injury. [PMID:11379817]
      10.Suzuki, Y Y, Nakabayashi, Y Y and Takahashi, R R. 2001-07-17 Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. [PMID:11447297]