Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

KDR

DescriptionVascular endothelial growth factor receptor 2

Gene and Protein Information

Gene ID3791
Uniprot Accession IDs A2RRS0 B5A925 C5IFA0 O60723 Q14178 VEGFR-2
Ensembl ID ENSP00000263923
Symbol FLK1 VEGFR2 FLK1 CD309 VEGFR VEGFR2
FamilyBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Sequence
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp461315KDRkinase insert domain receptor9598VGNC:755OMA, EggNOG
Macaque698293KDRkinase insert domain receptor9544Inparanoid, OMA, EggNOG
Mouse16542Kdrkinase insert domain protein receptor10090MGI:96683Inparanoid, OMA, EggNOG
Rat25589Kdrkinase insert domain receptor10116RGD:2965Inparanoid, OMA
Dog482154KDRkinase insert domain receptor9615VGNC:42331Inparanoid, OMA, EggNOG
Horse100033959KDRkinase insert domain receptor9796VGNC:19344Inparanoid, OMA, EggNOG
Cow407170KDRkinase insert domain receptor9913VGNC:30535Inparanoid, OMA, EggNOG
Pig397311KDRkinase insert domain receptor9823Inparanoid, OMA, EggNOG
Opossum100017311KDRkinase insert domain receptor13616Inparanoid, OMA, EggNOG
PlatypusKDRkinase insert domain receptor [Source:HGNC Symbol;Acc:HGNC:6307]9258OMA, EggNOG
Chicken395323KDRkinase insert domain receptor9031CGNC:10404Inparanoid, OMA
Anole lizard100551738kdrkinase insert domain receptor28377Inparanoid, OMA
Xenopus100487501kdrkinase insert domain receptor8364XB-GENE-6053213Inparanoid, OMA
Zebrafish554230kdrkinase insert domain receptor (a type III receptor tyrosine kinase)7955ZDB-GENE-041001-112Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    TK group    /    VEGFR family    /    Vascular endothelial growth factor receptor 2

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

The page will load shortly, Thanks for your patience!
NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Soldi, R R and 5 more authors. 1999-02-15 Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. [PMID:10022831]
      2.Kendall, R L RL and 5 more authors. 1999-03-05 Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. [PMID:10037737]
      3.Dougher, M M and Terman, B I BI. 1999-02-25 Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. [PMID:10102632]
      4.D'Angelo, G G and 5 more authors. 1999-05 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells. [PMID:10319320]
      5.Wen, Y Y, Edelman, J L JL, Kang, T T and Sachs, G G. 1999-05-19 Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1. [PMID:10329451]
      6.McTigue, M A MA and 10 more authors. 1999-03-15 Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. [PMID:10368301]
      7.Kranz, A A, Mattfeldt, T T and Waltenberger, J J. 1999-06-21 Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer. [PMID:10371349]
      8.Carmeliet, P P and 22 more authors. 1999-07-23 Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. [PMID:10428027]
      9.He, H H and 5 more authors. 1999-08-27 Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. [PMID:10455194]
      10.Petrova, T V TV, Makinen, T T and Alitalo, K K. 1999-11-25 Signaling via vascular endothelial growth factor receptors. [PMID:10579917]