CHRNA7

Description	Neuronal acetylcholine receptor subunit alpha-7

Gene and Protein Information

Gene ID	1139
Uniprot Accession IDs	P36544 A8K7Q4 B4DFS0 Q15826 Q8IUZ4 Q96RH2 Q99555 Q9BXH0
Ensembl ID	ENSP00000407546
Symbol	NACHRA7 NACHRA7 CHRNA7-2
Family	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
Sequence	MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	467639	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	9598		OMA, EggNOG
Macaque	574230	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	9544		Inparanoid, OMA, EggNOG
Mouse	11441	Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	10090	MGI:99779	Inparanoid, OMA, EggNOG
Rat	25302	Chrna7	cholinergic receptor nicotinic alpha 7 subunit	10116	RGD:2348	Inparanoid, OMA, EggNOG
Dog	488696	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	9615		Inparanoid, OMA, EggNOG
Horse	100060521	LOC100060521	neuronal acetylcholine receptor subunit alpha-7	9796		OMA, EggNOG
Pig	100415931	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	9823		OMA, EggNOG
Opossum	100027128	LOC100027128	neuronal acetylcholine receptor subunit alpha-7	13616		Inparanoid, EggNOG
Chicken	374001	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	9031	CGNC:48996	Inparanoid, OMA, EggNOG
Zebrafish	394199	chrna7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	7955	ZDB-GENE-040108-3	Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transporter    /    ligand-gated ion channel    /    Neuronal acetylcholine receptor subunit alpha-7
protein    /    transporter    /    ion channel    /    Neuronal acetylcholine receptor subunit alpha-7
protein    /    transporter    /    acetylcholine receptor    /    Neuronal acetylcholine receptor subunit alpha-7
protein    /    transporter    /    GABA receptor    /    Neuronal acetylcholine receptor subunit alpha-7
protein    /    transporter    /    receptor    /    Neuronal acetylcholine receptor subunit alpha-7

DTO Classes
protein / Ion channel / Neurotransmitter receptor, Cys loop, ligand-gated ion channel (LIC) family / Acetylcholine receptor subfamily / Alpha-7/CHRNA7 sub-subfamily / Neuronal acetylcholine receptor subunit alpha-7

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Availability	View Details

Associated Antibodies

Name	Specifications	Species reactivity	Application	Availability	View Details

Related active small molecules

A total of 83 itemsPrev12 3 4 5…9 NextTopage

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

A total of 107 itemsPrev12 3 4 5…11 NextTopage

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Name	Direct Associated Targets	Disease Type	Mondoid

Bibliography

A total of 270 itemsPrev12 3 4 5…27 NextTopage

1.Curtis, L L and 12 more authors. 1999-04-16 No evidence for linkage between schizophrenia and markers at chromosome 15q13-14. [PMID:10206225]
2.Sander, T T and 12 more authors. 1999-04-16 Evaluation of a putative major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q14. [PMID:10206240]
3.Sato, K Z KZ and 6 more authors. 1999-04-30 Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. [PMID:10336173]
4.Wang, H Y HY and 5 more authors. 2000-02-25 beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. [PMID:10681545]
5.Schuller, H M HM, Jull, B A BA, Sheppard, B J BJ and Plummer, H K HK. 2000-03-30 Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. [PMID:10771023]
6.Lai, I C IC, Hong, C J CJ and Tsai, S J SJ. 2001-01 Association study of a nicotinic receptor variant with schizophrenic disorders. [PMID:11150893]
7.Kihara, T T and 7 more authors. 2001-04-27 alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. [PMID:11278378]
8.Dineley, K T KT and 5 more authors. 2001-06-15 Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. [PMID:11404397]
9.Freedman, R R and 11 more authors. 2001-01-08 Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). [PMID:11424985]
10.Liou, Y J YJ and 5 more authors.Association analysis of the partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant and Alzheimer's disease. [PMID:11455129]