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SLC1A5

DescriptionNeutral amino acid transporter B(0)

Gene and Protein Information

Gene ID6510
Uniprot Accession IDs A8K9H5 B4DR77 B4DWS4 B7ZB81 D0EYG6 E9PC01 O95720 Q96RL9 Q9BWQ3 Q9UNP2 ATB(0)
Ensembl ID ENSP00000444408
Symbol ASCT2 M7V1 RDR RDRC R16 AAAT ATBO M7V1 RDRC ASCT2 M7VS1
FamilyBelongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
Sequence
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp456155SLC1A5solute carrier family 1 member 59598VGNC:7786OMA, EggNOG
Macaque716843SLC1A5solute carrier family 1 member 59544OMA, EggNOG
Mouse20514Slc1a5solute carrier family 1 (neutral amino acid transporter), member 510090MGI:105305Inparanoid, OMA, EggNOG
Rat292657Slc1a5solute carrier family 1 member 510116RGD:708512Inparanoid, OMA, EggNOG
Dog484425SLC1A5solute carrier family 1 member 59615VGNC:46265Inparanoid, OMA, EggNOG
Horse100146913SLC1A5solute carrier family 1 member 59796VGNC:23064Inparanoid, OMA, EggNOG
Cow282355SLC1A5solute carrier family 1 member 59913VGNC:34715Inparanoid, OMA, EggNOG
Opossum100021149SLC1A5solute carrier family 1 member 513616Inparanoid, OMA, EggNOG
Anole lizard100562974slc1a5solute carrier family 1 member 528377Inparanoid, OMA
Xenopus493489slc1a5solute carrier family 1 member 58364XB-GENE-482596Inparanoid, OMA
Zebrafish100002129slc1a5solute carrier family 1 (neutral amino acid transporter), member 57955ZDB-GENE-070501-4Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transporter    /    cation transporter    /    Neutral amino acid transporter B(0)
DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC1 family of amino acid transporters    /    Alanine/serine/cysteine transporter subfamily    /    Neutral amino acid transporter B(0)

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Idactamab (anti-SLC1A5)Cynomolgus monkey,Human
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Rasko, J E JE, Battini, J L JL, Gottschalk, R J RJ, Mazo, I I and Miller, A D AD. 1999-03-02 The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. [PMID:10051606]
      2.Tailor, C S CS, Nouri, A A, Zhao, Y Y, Takeuchi, Y Y and Kabat, D D. 1999-05 A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. [PMID:10196349]
      3.Bröer, A A, Wagner, C C, Lang, F F and Bröer, S S. 2000-03-15 Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance. [PMID:10698697]
      4.Tailor, C S CS, Marin, M M, Nouri, A A, Kavanaugh, M P MP and Kabat, D D. 2001-07-20 Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. [PMID:11350958]
      5.Larriba, S S and 6 more authors. 2001-11 ATB(0)/SLC1A5 gene. Fine localisation and exclusion of association with the intestinal phenotype of cystic fibrosis. [PMID:11781704]
      6.Lavillette, Dimitri D and 5 more authors. 2002-07 The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. [PMID:12050356]
      7.Kudo, Y Y and Boyd, C A R CA. 2002-08 Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. [PMID:12175968]
      8.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      9.Potter, S J SJ, Lu, A A, Wilcken, B B, Green, K K and Rasko, J E J JE. 2002-10 Hartnup disorder: polymorphisms identified in the neutral amino acid transporter SLC1A5. [PMID:12555937]
      10.Marin, Mariana M, Lavillette, Dimitri D, Kelly, Sean M SM and Kabat, David D. 2003-03 N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. [PMID:12584318]