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ADCY8

DescriptionAdenylate cyclase type 8

Gene and Protein Information

Gene ID114
Uniprot Accession IDs P40145
Ensembl ID ENSP00000286355
Symbol AC8 ADCY3 HBAC1
FamilyBelongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Sequence
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp464400ADCY8adenylate cyclase 89598VGNC:12015OMA, EggNOG
Macaque695792ADCY8adenylate cyclase 89544Inparanoid, OMA, EggNOG
Mouse11514Adcy8adenylate cyclase 810090MGI:1341110Inparanoid, OMA, EggNOG
Rat29241Adcy8adenylate cyclase 810116RGD:2036Inparanoid, OMA, EggNOG
Dog482045ADCY8adenylate cyclase 89615VGNC:37625Inparanoid, OMA, EggNOG
Horse100057796ADCY8adenylate cyclase 89796VGNC:15092Inparanoid, OMA, EggNOG
Cow535017ADCY8adenylate cyclase 89913VGNC:25649Inparanoid, OMA, EggNOG
Opossum100026554ADCY8adenylate cyclase 813616Inparanoid, OMA, EggNOG
Platypus100077908ADCY8adenylate cyclase 89258Inparanoid, OMA, EggNOG
Anole lizard100556578adcy8adenylate cyclase 828377Inparanoid, OMA, EggNOG
Zebrafish100148976adcy8adenylate cyclase 8 (brain)7955ZDB-GENE-070912-197OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Approved Drugs

  1. colforsin daropateTetrahydrouridine

    RETTchemnull

    pEC50: 7.03

Associated Active Ligands

  1. ForskolinTetrahydrouridine

    RETTchemnull

    EC50 p: 7.03

  2. ethyl 3-(2,4-dichlorobenzyl)-2-oxoindoline-3-carboxylateTetrahydrouridine

    RETTchemnull

    EC50 p: 6.98

Associated Diseases

NameDisease TypeMondoid
astrocytic gliomaExpression AtlasMONDO:0021636
Astrocytoma, PilocyticExpression AtlasMONDO:0016691
atypical teratoid / rhabdoid tumorExpression AtlasMONDO:0020560
group 3 medulloblastomaExpression AtlasMONDO:0007959
medulloblastoma, large-cellExpression AtlasMONDO:0002791
primitive neuroectodermal tumorExpression AtlasMONDO:0005462
psoriasisExpression AtlasMONDO:0005083
Diabetic AngiopathiesCTDMONDO:0000960
HyperkinesisCTD
Mood DisordersCTDMONDO:0005371

Pathway

Data SourceNameExplore more targetsExplore in Source
KEGGEndocrine resistance100 Targetspath:hsa01522
KEGGInflammatory mediator regulation of TRP channels102 Targetspath:hsa04750
KEGGPlatelet activation126 Targetspath:hsa04611
KEGGParathyroid hormone synthesis, secretion and action110 Targetspath:hsa04928
KEGGCortisol synthesis and secretion68 Targetspath:hsa04927
KEGGRelaxin signaling pathway132 Targetspath:hsa04926
KEGGAldosterone synthesis and secretion101 Targetspath:hsa04925
KEGGRegulation of lipolysis in adipocytes58 Targetspath:hsa04923
KEGGOxytocin signaling pathway155 Targetspath:hsa04921
KEGGGastric acid secretion78 Targetspath:hsa04971