ABCB11

Description	Bile salt export pump

Gene and Protein Information

Gene ID	8647
Uniprot Accession IDs	Q53TL2 Q9UNB2
Ensembl ID	ENSP00000263817
Symbol	BSEP BSEP PGY4 SPGP ABC16 BRIC2 PFIC2 PFIC-2
Family	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Sequence	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Macaque	709261	ABCB11	ATP binding cassette subfamily B member 11	9544		Inparanoid, OMA
Mouse	27413	Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	10090	MGI:1351619	Inparanoid, OMA
Rat	83569	Abcb11	ATP binding cassette subfamily B member 11	10116	RGD:619930	Inparanoid, OMA
Dog	488390	ABCB11	ATP binding cassette subfamily B member 11	9615	VGNC:37433	Inparanoid, OMA
Horse	100052359	ABCB11	ATP binding cassette subfamily B member 11	9796	VGNC:14909	Inparanoid, OMA
Cow	531150	ABCB11	ATP binding cassette subfamily B member 11	9913	VGNC:25463	Inparanoid, OMA
Pig	100518154	ABCB11	ATP binding cassette subfamily B member 11	9823		Inparanoid, OMA
Opossum	100024107	ABCB11	ATP binding cassette subfamily B member 11	13616		Inparanoid, OMA
Chicken	424170	ABCB11	ATP binding cassette subfamily B member 11	9031	CGNC:8276	Inparanoid, OMA
Zebrafish	571189	abcb11b	ATP-binding cassette, sub-family B (MDR/TAP), member 11b	7955	ZDB-GENE-050517-14	Inparanoid, OMA
C. elegans	178215	pgp-1	Multidrug resistance protein pgp-1	6239		Inparanoid, OMA

Protein Classes

PANTHER Classes
protein / serine protease / Bile salt export pump
protein / cysteine protease / Bile salt export pump

DTO Classes
protein / Transporter / ATP-binding cassette transporter family / ABCB subfamily / Bile salt export pump

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source