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SLC7A10

DescriptionAsc-type amino acid transporter 1

Gene and Protein Information

Gene ID56301
Uniprot Accession IDs B2RE84 Asc-1
Ensembl ID ENSP00000253188
Symbol ASC1 ASC1 asc-1 HASC-1
FamilyBelongs to the amino acid-polyamine-organocation (APC) superfamily.
Sequence
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp468817SLC7A10solute carrier family 7 member 109598VGNC:12106OMA, EggNOG
Macaque100430378SLC7A10solute carrier family 7 member 109544OMA, EggNOG
Mouse53896Slc7a10solute carrier family 7 (cationic amino acid transporter, y+ system), member 1010090MGI:1858261Inparanoid, OMA, EggNOG
Rat114518Slc7a10solute carrier family 7 member 1010116RGD:621672Inparanoid, OMA, EggNOG
Dog484599SLC7A10solute carrier family 7 member 109615VGNC:46471Inparanoid, OMA, EggNOG
Horse100056323SLC7A10solute carrier family 7 member 109796VGNC:23266Inparanoid, OMA
Cow100126273SLC7A10solute carrier family 7 member 109913VGNC:34925Inparanoid, OMA, EggNOG
Pig100525049SLC7A10solute carrier family 7 member 109823Inparanoid, OMA, EggNOG
Opossum100012622SLC7A10solute carrier family 7 member 1013616Inparanoid, EggNOG
PlatypusSLC7A10solute carrier family 7 member 10 [Source:HGNC Symbol;Acc:HGNC:11058]9258OMA, EggNOG
Chicken415774SLC7A10solute carrier family 7 member 109031CGNC:3505Inparanoid, OMA, EggNOG
Anole lizard100555939slc7a10solute carrier family 7 member 1028377Inparanoid, OMA
Zebrafish559395slc7a10bsolute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10b7955ZDB-GENE-121105-2OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)    /    SLC7 family    /    Asc-type amino acid transporter 1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adult high grade glioma4998Expression AtlasMONDO:0100342
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      ependymoma5607Expression AtlasMONDO:0021191
      glioblastoma5998Expression AtlasMONDO:0018177
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      malignant mesothelioma3244Expression AtlasMONDO:0006292
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791

      Bibliography

      1.Fukasawa, Y Y and 8 more authors. 2000-03-31 Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. [PMID:10734121]
      2.Nakauchi, J J and 11 more authors. 2000-06-30 Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity. [PMID:10863037]
      3.Dehal, P P and 20 more authors. 2001-07-06 Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. [PMID:11441184]
      4.Leclerc, D D, Wu, Q Q, Ellis, J R JR, Goodyer, P P and Rozen, R R. 2001-08 Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? [PMID:11509015]
      5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      6.Pineda, Marta M and 11 more authors. 2004-10 The amino acid transporter asc-1 is not involved in cystinuria. [PMID:15458438]
      7.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      8.Xu, Daosong D and Hemler, Martin E ME. 2005-08 Metabolic activation-related CD147-CD98 complex. [PMID:15901826]
      9. and Bröer, Stefan S. 2008-01 Amino acid transport across mammalian intestinal and renal epithelia. [PMID:18195088]
      10.Gaudet, Pascale P, Livstone, Michael S MS, Lewis, Suzanna E SE and Thomas, Paul D PD. 2011-09 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. [PMID:21873635]