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| Description | Actin, cytoplasmic 1 |
|---|
Gene and Protein Information
| Gene ID | 60 |
|---|---|
| Uniprot Accession IDs | P60709 P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5 |
| Ensembl ID | ENSP00000349960 |
| Symbol | BRWS1 PS1TP5BP1 |
| Family | Belongs to the actin family. |
| Sequence | MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 450133 | ACTB | actin beta | 9598 | VGNC:50814 | Inparanoid, OMA, EggNOG |
| Mouse | 11461 | Actb | actin, beta | 10090 | MGI:87904 | Inparanoid, OMA, EggNOG |
| Rat | 81822 | Actb | actin, beta | 10116 | RGD:628837 | Inparanoid, OMA |
| Dog | 403580 | ACTB | actin beta | 9615 | Inparanoid, OMA, EggNOG | |
| Horse | 100050139 | ACTG1 | actin gamma 1 | 9796 | VGNC:51374 | OMA, EggNOG |
| Horse | 100033878 | ACTB | actin beta | 9796 | Inparanoid, OMA | |
| Cow | 280979 | ACTB | actin beta | 9913 | Inparanoid, OMA | |
| Cow | 404122 | ACTG1 | actin gamma 1 | 9913 | OMA, EggNOG | |
| Pig | 414396 | ACTB | actin beta | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100011351 | ACTB | actin beta | 13616 | Inparanoid, OMA | |
| Opossum | 100025924 | ACTG1 | actin gamma 1 | 13616 | OMA, EggNOG | |
| Platypus | 100078865 | ACTB | actin beta | 9258 | Inparanoid, OMA, EggNOG | |
| Chicken | 396526 | ACTB | actin, beta | 9031 | CGNC:49855 | Inparanoid, OMA |
| Chicken | 415296 | ACTG1 | Actin, gamma 1 | 9031 | CGNC:49945 | OMA, EggNOG |
| Anole lizard | 100564373 | actg1 | actin gamma 1 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 407952 | actb | actin, beta | 8364 | XB-GENE-490883 | Inparanoid, OMA, EggNOG |
| Zebrafish | 57934 | actb1 | actin, beta 1 | 7955 | ZDB-GENE-000329-1 | OMA, EggNOG |
| Fruitfly | 35526 | Act42A | Actin 42A | 7227 | FBgn0000043 | Inparanoid, OMA |
Protein Classes
PANTHER Classes
protein / cytoskeletal protein / actin and actin related protein / Actin, cytoplasmic 1
protein / cytoskeletal protein / actin and actin related protein / Actin, cytoplasmic 1
DTO Classes
protein / Cellular structure / Actin family cytoskeletal protein / Actin and actin related protein / Actin, cytoplasmic 1
protein / Cellular structure / Actin family cytoskeletal protein / Actin and actin related protein / Actin, cytoplasmic 1
Associated Antibodies
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|---|---|---|
| Dystonia, juvenile-onset | 0 | UniProt Disease | |
| Baraitser-Winter syndrome 1 | 1 | UniProt Disease | MONDO:0009470 |
| Baraitser-Winter Syndrome 1 | 1 | Monarch | MONDO:0009470 |
| Developmental malformations-deafness-dystonia syndrome | 1 | Monarch | MONDO:0011823 |
| astrocytoma | 3773 | Expression Atlas | MONDO:0021636 |
| Astrocytoma, Pilocytic | 3186 | Expression Atlas | MONDO:0016691 |
| atypical teratoid/rhabdoid tumor | 5491 | Expression Atlas | MONDO:0020560 |
| COPD | 393 | Expression Atlas | MONDO:0005002 |
| dermatomyositis | 987 | Expression Atlas | MONDO:0016367 |
| Down syndrome | 498 | Expression Atlas | MONDO:0008608 |
Bibliography
| 1.Perrin-Tricaud, C C, Davoust, J J and Jones, I M IM. 1999-03-01 Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin. [PMID:10049817] |
| 2.Liu, B B and 5 more authors. 1999-04 Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. [PMID:10074138] |
| 3.Phelan, M L ML, Sif, S S, Narlikar, G J GJ and Kingston, R E RE. 1999-02 Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. [PMID:10078207] |
| 4.Suetsugu, S S, Miki, H H and Takenawa, T T. 1999-06-24 Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. [PMID:10381382] |
| 5.Bertagnolli, M E ME, Hudson, L A LA and Stetsenko, G Y GY. 1999-07-14 Selective association of the tyrosine kinases Src, Fyn, and Lyn with integrin-rich actin cytoskeletons of activated, nonaggregated platelets. [PMID:10403844] |
| 6.Nunoi, H H and 6 more authors. 1999-07-20 A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection. [PMID:10411937] |
| 7.Moncman, C L CL and Wang, K K. 1999 Functional dissection of nebulette demonstrates actin binding of nebulin-like repeats and Z-line targeting of SH3 and linker domains. [PMID:10470015] |
| 8.Ludwig, H C HC, Rausch, S S, Schallock, K K and Markakis, E E.Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. [PMID:10470109] |
| 9.Nodelman, I M IM, Bowman, G D GD, Lindberg, U U and Schutt, C E CE. 1999-12-17 X-ray structure determination of human profilin II: A comparative structural analysis of human profilins. [PMID:10600384] |
| 10.Kang, F F, Purich, D L DL and Southwick, F S FS. 1999-12-24 Profilin promotes barbed-end actin filament assembly without lowering the critical concentration. [PMID:10601251] |