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AHR

DescriptionAryl hydrocarbon receptor

Gene and Protein Information

Gene ID196
Uniprot Accession IDs A4D130 Q13728 Q13803 Q13804 Ah receptor
Ensembl ID ENSP00000242057
Symbol BHLHE76 RP85 bHLHe76
Sequence
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTHVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGFL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463278AHRaryl hydrocarbon receptor9598VGNC:4253OMA, EggNOG
Macaque714254AHRaryl hydrocarbon receptor9544Inparanoid, OMA, EggNOG
Mouse11622Ahraryl-hydrocarbon receptor10090MGI:105043Inparanoid, OMA, EggNOG
Rat25690Ahraryl hydrocarbon receptor10116RGD:2074Inparanoid, OMA, EggNOG
Dog475251AHRaryl hydrocarbon receptor9615VGNC:54752Inparanoid, OMA, EggNOG
Cow280714AHRaryl hydrocarbon receptor9913Inparanoid, OMA, EggNOG
Pig396654AHRaryl hydrocarbon receptor9823OMA, EggNOG
Chicken373907AHRaryl hydrocarbon receptor9031CGNC:8232Inparanoid, OMA
Xenopus613065ahraryl hydrocarbon receptor8364XB-GENE-983107Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    receptor    /    Aryl hydrocarbon receptor
protein    /    transcription factor    /    basic helix-loop-helix transcription factor    /    Aryl hydrocarbon receptor
DTO Classes
protein    /    Transcription factor    /    Basic helix-loop-helix transcription factor    /    Aryl hydrocarbon receptor

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      active ulcerative colitis2513Expression AtlasMONDO:0005101
      acute myeloid leukemia927Expression AtlasMONDO:0018874
      aldosterone-producing adenoma698Expression AtlasMONDO:0004972
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      breast cancer3880Expression AtlasMONDO:0007254
      cystic fibrosis1831Expression AtlasMONDO:0009061
      diabetes mellitus1167Expression AtlasMONDO:0005015
      gastric carcinoma1287Expression AtlasMONDO:0004950
      hydrolethalus syndrome118Expression AtlasMONDO:0006037
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286

      Bibliography

      1.Abbott, B D BD and 5 more authors. 1999-01 AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture. [PMID:10048154]
      2.Nguyen, T A TA, Hoivik, D D, Lee, J E JE and Safe, S S. 1999-07-15 Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. [PMID:10395741]
      3.Kumar, M B MB, Tarpey, R W RW and Perdew, G H GH. 1999-08-06 Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. [PMID:10428779]
      4.Wang, F F, Wang, W W and Safe, S S. 1999-08-31 Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex. [PMID:10471301]
      5.Davarinos, N A NA and Pollenz, R S RS. 1999-10-01 Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export. [PMID:10497241]
      6.Klinge, C M CM, Kaur, K K and Swanson, H I HI. 2000-01-01 The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. [PMID:10620335]
      7.Smart, J J and Daly, A K AK. 2000-02 Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. [PMID:10739168]
      8.Hulkko, S M SM, Wakui, H H and Zilliacus, J J. 2000-08-01 The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function. [PMID:10903152]
      9.Petrulis, J R JR, Hord, N G NG and Perdew, G H GH. 2000-12-01 Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. [PMID:10986286]
      10.Tohkin, M M, Fukuhara, M M, Elizondo, G G, Tomita, S S and Gonzalez, F J FJ. 2000-10 Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A. [PMID:10999956]