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GNAS

DescriptionProtein ALEX

Gene and Protein Information

Gene ID2778
Uniprot Accession IDs A2A2S4
Ensembl ID ENSP00000360141
Symbol GNAS1 AHO GSA GSP POH GPSA NESP SCG6 SgVI GNAS1 PITA3 C20orf45
FamilyBelongs to the ALEX family.
Sequence
MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFSYRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAHPRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIAAAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKRWATCVRTACCF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque694289LOC694289guanine nucleotide-binding protein G(s) subunit alpha9544OMA, EggNOG
Mouse14683GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus10090MGI:95777Inparanoid, EggNOG

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Tinschert, S S, Gerl, H H, Gewies, A A, Jung, H P HP and Nürnberg, P P. 1999-03-12 McCune-Albright syndrome: clinical and molecular evidence of mosaicism in an unusual giant patient. [PMID:10190480]
      2.Warner, D R DR and Weinstein, L S LS. 1999-04-13 A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity. [PMID:10200251]
      3.Yu, D D and 5 more authors. 1999-09 Identification of two novel deletion mutations within the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy. [PMID:10487696]
      4.Kühn, B B and Gudermann, T T. 1999-09-21 The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2. [PMID:10493819]
      5.Waldhoer, M M, Wise, A A, Milligan, G G, Freissmuth, M M and Nanoff, C C. 1999-10-22 Kinetics of ternary complex formation with fusion proteins composed of the A(1)-adenosine receptor and G protein alpha-subunits. [PMID:10521440]
      6.Riminucci, M M and 7 more authors. 1999-11 A novel GNAS1 mutation, R201G, in McCune-albright syndrome. [PMID:10571700]
      7.Grammatopoulos, D K DK and 6 more authors. 1999-12 A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. [PMID:10598591]
      8.Weiss, U U and 5 more authors. 2000-03 Neuroendocrine secretory protein 55 (NESP55): alternative splicing onto transcripts of the GNAS gene and posttranslational processing of a maternally expressed protein. [PMID:10729789]
      9.Dias Neto, E E and 23 more authors. 2000-03-28 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. [PMID:10737800]
      10.Hayward, B E BE and Bonthron, D T DT. 2000-03-22 An imprinted antisense transcript at the human GNAS1 locus. [PMID:10749992]