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STAT5A

DescriptionSignal transducer and activator of transcription 5A

Gene and Protein Information

Gene ID6776
Uniprot Accession IDs P42229 Q1KLZ6
Ensembl ID ENSP00000341208
Symbol STAT5 MGF STAT5
FamilyBelongs to the transcription factor STAT family.
Sequence
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454681STAT5Asignal transducer and activator of transcription 5A9598VGNC:9664OMA, EggNOG
Macaque574129STAT5Asignal transducer and activator of transcription 5A9544Inparanoid, OMA, EggNOG
Mouse20850Stat5asignal transducer and activator of transcription 5A10090MGI:103036Inparanoid, OMA, EggNOG
Rat24918Stat5asignal transducer and activator of transcription 5A10116RGD:3773Inparanoid, OMA, EggNOG
Dog490968STAT5Asignal transducer and activator of transcription 5A9615VGNC:46891Inparanoid, OMA, EggNOG
Horse100052904STAT5Asignal transducer and activator of transcription 5A9796VGNC:23667Inparanoid, OMA, EggNOG
Cow282375STAT5Asignal transducer and activator of transcription 5A9913VGNC:35372Inparanoid, OMA, EggNOG
Pig397550STAT5Asignal transducer and activator of transcription 5A9823Inparanoid, OMA, EggNOG
Opossum100012174LOC100012174signal transducer and activator of transcription 5A13616OMA, EggNOG
Anole lizard100566752LOC100566752signal transducer and activator of transcription 5B28377OMA, EggNOG
Xenopus100495240stat5bsignal transducer and activator of transcription 5B8364XB-GENE-5913743Inparanoid, OMA, EggNOG
Zebrafish369197stat5asignal transducer and activator of transcription 5a7955ZDB-GENE-030820-2OMA, EggNOG
C. elegans178465sta-1Signal transducer and activator of transcription 16239OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    Signal transducer and activator of transcription 5A
protein    /    nucleic acid binding    /    Signal transducer and activator of transcription 5A
DTO Classes
protein    /    Nucleic acid binding    /    Signal transducer and activator of transcription 5A

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      group 4 medulloblastoma7142Expression AtlasMONDO:0007959
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      lung cancer4468Expression AtlasMONDO:0008903
      malignant mesothelioma3244Expression AtlasMONDO:0006292
      osteosarcoma7970Expression AtlasMONDO:0009807
      Adenocarcinoma115CTDMONDO:0004970
      Adenocarcinoma115CTDMONDO:0003197
      Adenocarcinoma115CTDMONDO:0005606
      Adenocarcinoma115CTDMONDO:0045059

      Bibliography

      1.Witthuhn, B A BA, Williams, M D MD, Kerawalla, H H and Uckun, F M FM. 1999-01 Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. [PMID:10037026]
      2.Rodríguez-Frade, J M JM and 8 more authors. 1999-02-22 Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis. [PMID:10037796]
      3.Pircher, T J TJ, Petersen, H H, Gustafsson, J A JA and Haldosén, L A LA. 1999-04 Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a. [PMID:10194762]
      4.Brizzi, M F MF, Dentelli, P P, Rosso, A A, Yarden, Y Y and Pegoraro, L L. 1999-06-11 STAT protein recruitment and activation in c-Kit deletion mutants. [PMID:10358045]
      5.Olayioye, M A MA, Beuvink, I I, Horsch, K K, Daly, J M JM and Hynes, N E NE. 1999-06-11 ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. [PMID:10358079]
      6.Socolovsky, M M, Fallon, A E AE, Wang, S S, Brugnara, C C and Lodish, H F HF. 1999-07-23 Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. [PMID:10428030]
      7.Isaksen, D E DE and 5 more authors. 1999-12-01 Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. [PMID:10570284]
      8.Soldaini, E E and 5 more authors. 2000-01 DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. [PMID:10594041]
      9.Delespine-Carmagnat, M M, Bouvier, G G and Bertoglio, J J. 2000-01 Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. [PMID:10602027]
      10.Yu, C L CL, Jin, Y J YJ and Burakoff, S J SJ. 2000-01-07 Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. [PMID:10617656]