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TBXA2R

DescriptionThromboxane A2 receptor

Gene and Protein Information

Gene ID6915
Uniprot Accession IDs O75228 Q6DK52 Q9UCY1 Q9UCY2 TXA2-R
Ensembl ID ENSP00000393333
Symbol TXA2-R BDPLT13
FamilyBelongs to the G-protein coupled receptor 1 family.
Sequence
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Mouse21390Tbxa2rthromboxane A2 receptor10090MGI:98496Inparanoid, OMA, EggNOG
Rat24816Tbxa2rthromboxane A2 receptor10116RGD:3825Inparanoid, OMA, EggNOG
Dog485056TBXA2Rthromboxane A2 receptor9615VGNC:47177Inparanoid, OMA, EggNOG
Cow538783TBXA2Rthromboxane A2 receptor9913VGNC:35673Inparanoid, OMA, EggNOG
Opossum100010675TBXA2Rthromboxane A2 receptor13616Inparanoid, OMA, EggNOG
Platypus100090815TBXA2Rthromboxane A2 receptor9258Inparanoid, OMA, EggNOG
Xenopus100145351tbxa2rthromboxane A2 receptor8364XB-GENE-996433Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    receptor    /    G-protein coupled receptor    /    Thromboxane A2 receptor
DTO Classes
protein    /    G-protein coupled receptor    /    Class A rhodopsin like    /    Thromboxane A2 receptor

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Bleeding disorder, platelet-type 130UniProt Disease
      Bleeding Disorder, Platelet-Type, 13, Susceptibility to1MonarchMONDO:0013524
      adult high grade glioma4998Expression AtlasMONDO:0100342
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      glioblastoma5998Expression AtlasMONDO:0018177
      osteosarcoma7970Expression AtlasMONDO:0009807
      psoriasis6696Expression AtlasMONDO:0005083
      spina bifida1039Expression AtlasMONDO:0008449
      Asthma, Aspirin-Induced0CTD

      Bibliography

      1.Becker, K P KP, Garnovskaya, M M, Gettys, T T and Halushka, P V PV. 1999-07-08 Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. [PMID:10395940]
      2.Barr, C L CL and 7 more authors. 1999-08-20 Genome scan for linkage to Gilles de la Tourette syndrome. [PMID:10402514]
      3.Zhou, H H, Yan, F F and Tai, H H HH. 2001-09 Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. [PMID:11504827]
      4.Vezza, Roberta R, Mezzasoma, Anna Maria AM, Venditti, Gigliola G and Gresele, Paolo P. 2002-01 Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. [PMID:11848439]
      5.Tanaka, Keiko K and 7 more authors. 2002-04-05 Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis. [PMID:11922633]
      6.Leung, Ting Fan TF and 5 more authors. 2002-02 Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children. [PMID:12000493]
      7.Coyle, Adrian T AT, Miggin, Sinead M SM and Kinsella, B Therese BT. 2002-08 Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms. [PMID:12180983]
      8.Rochdi, Moulay Driss MD and 5 more authors. 2002-10-25 Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). [PMID:12193606]
      9.Saffak, T T and Nüsing, R M RM. 2002-07 The 5' region of the human thromboxane A(2) receptor gene. [PMID:12213432]
      10.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]