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TARDBP

DescriptionTAR DNA-binding protein 43

Gene and Protein Information

Gene ID23435
Uniprot Accession IDs A4GUK4 A4GUK5 A4GUK6 B2R629 B4DJ45 E2PU12 Q53H27 Q6FI92 Q96DJ0 TDP-43
Ensembl ID ENSP00000240185
Symbol TDP43 ALS10 TDP-43
Sequence
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp107974879TARDBPTAR DNA binding protein9598VGNC:10944OMA, EggNOG
Macaque100423163TARDBPTAR DNA binding protein9544Inparanoid, OMA, EggNOG
Mouse230908TardbpTAR DNA binding protein10090MGI:2387629Inparanoid, OMA, EggNOG
Rat298648TardbpTAR DNA binding protein10116RGD:1310906Inparanoid, OMA
Dog478234TARDBPTAR DNA binding protein9615VGNC:47109Inparanoid, OMA, EggNOG
Horse100051482TARDBPTAR DNA binding protein9796VGNC:23876Inparanoid, OMA, EggNOG
Cow540632TARDBPTAR DNA binding protein9913VGNC:35603Inparanoid, OMA, EggNOG
Pig100739753TARDBPTAR DNA binding protein9823OMA, EggNOG
Platypus100078687TARDBPTAR DNA binding protein9258Inparanoid, OMA, EggNOG
Chicken419453TARDBPTAR DNA binding protein9031CGNC:2099Inparanoid, OMA, EggNOG
Xenopus394651tardbpTAR DNA binding protein8364XB-GENE-974453Inparanoid, OMA, EggNOG
Zebrafish325052tardbpTAR DNA binding protein7955ZDB-GENE-030131-3777Inparanoid, OMA
Zebrafish386630tardbplTAR DNA binding protein, like7955ZDB-GENE-031030-1OMA, EggNOG
C. elegans174436tdp-1Tar DNA-binding protein homolog 16239Inparanoid, OMA, EggNOG
Fruitfly39665CG7804CG7804 gene product from transcript CG7804-RA7227FBgn0036496Inparanoid, EggNOG

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Amyotrophic lateral sclerosis 100UniProt Disease
      Frontotemporal Lobar Degeneration0Monarch
      Amyotrophic Lateral Sclerosis 10 With or Without Frontotemporal Dementia1MonarchMONDO:0012790
      amyotrophic lateral sclerosis387MonarchMONDO:0004976
      acute myeloid leukemia927Expression AtlasMONDO:0018874
      astrocytoma3773Expression AtlasMONDO:0021636
      dermatomyositis987Expression AtlasMONDO:0016367
      diabetes mellitus1167Expression AtlasMONDO:0005015
      juvenile dermatomyositis1263Expression AtlasMONDO:0008054
      lung carcinoma2913Expression AtlasMONDO:0005138

      Bibliography

      1.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      2.Wiemann, S S and 23 more authors. 2001-03 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. [PMID:11230166]
      3.Simpson, J C JC, Wellenreuther, R R, Poustka, A A, Pepperkok, R R and Wiemann, S S. 2000-09 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. [PMID:11256614]
      4.Buratti, E E and 5 more authors. 2001-04-02 Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. [PMID:11285240]
      5.Buratti, E E and Baralle, F E FE. 2001-09-28 Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9. [PMID:11470789]
      6.Wang, I-Fan IF, Reddy, Narsa M NM and Shen, C-K James CK. 2002-10-15 Higher order arrangement of the eukaryotic nuclear bodies. [PMID:12361981]
      7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      8.Lehner, Ben B and Sanderson, Christopher M CM. 2004-07 A protein interaction framework for human mRNA degradation. [PMID:15231747]
      9.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      10.Wiemann, Stefan S and 11 more authors. 2004-10 From ORFeome to biology: a functional genomics pipeline. [PMID:15489336]