Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

CES1

DescriptionLiver carboxylesterase 1

Gene and Protein Information

Gene ID1066
Uniprot Accession IDs A6NIM1 A8K3K8 A8K844 E9PAU8 P82127 Q00015 Q13657 Q14062 Q16737 Q16788 Q549X7 Q549X8 Q86UK2 Q96EE8 Q9UC52 Q9UDG8 Q9UK77 Q9ULY2
Ensembl ID ENSP00000353720
Symbol CES2 SES1 CEH REH TGH ACAT CE-1 CES2 HMSE SES1 HMSE1 PCE-1 hCE-1
FamilyBelongs to the type-B carboxylesterase/lipase family.
Sequence
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Mouse104158Ces1dcarboxylesterase 1D10090MGI:2148202Inparanoid, OMA
Rat113902Ces1dcarboxylesterase 1D10116RGD:70896Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    serine protease    /    Liver carboxylesterase 1
protein    /    lipase    /    Liver carboxylesterase 1
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Lipase    /    Liver carboxylesterase 1

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Yan, B B, Matoney, L L and Yang, D D. 1999-09 Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. [PMID:10452915]
      2.Mori, M M, Hosokawa, M M, Ogasawara, Y Y, Tsukada, E E and Chiba, K K. 1999-09-10 cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. [PMID:10518925]
      3.Islam, M R MR, Waheed, A A, Shah, G N GN, Tomatsu, S S and Sly, W S WS. 1999-12-01 Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction. [PMID:10562416]
      4. and Ghosh, S S. 2000-01-24 Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. [PMID:11015575]
      5.Ghosh, S S and Natarajan, R R. 2001-06-22 Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. [PMID:11409902]
      6.Alam, Mustafa M, Ho, Samuel S, Vance, Dennis E DE and Lehner, Richard R. 2002-02 Heterologous expression, purification, and characterization of human triacylglycerol hydrolase. [PMID:11812220]
      7.Satoh, Tetsuo T and 5 more authors. 2002-05 Current progress on esterases: from molecular structure to function. [PMID:11950776]
      8.Alam, Mustafa M, Vance, Dennis E DE and Lehner, Richard R. 2002-05-28 Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site. [PMID:12022871]
      9.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      10.Bencharit, Sompop S, Morton, Christopher L CL, Xue, Yu Y, Potter, Philip M PM and Redinbo, Matthew R MR. 2003-05 Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. [PMID:12679808]