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CES2

DescriptionCocaine esterase

Gene and Protein Information

Gene ID8824
Uniprot Accession IDs A0A024R6X1 A8K367 Q16859 Q5MAB8 Q7Z366 Q8IUP4 Q8TCP8
Ensembl ID ENSP00000317842
Symbol ICE iCE CE-2 PCE-2 CES2A1
FamilyBelongs to the type-B carboxylesterase/lipase family.
Sequence
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp467996CES2carboxylesterase 29598VGNC:5729OMA, EggNOG
Macaque697524LOC697524cocaine esterase-like9544OMA, EggNOG
Mouse436059Ces2hcarboxylesterase 2H10090MGI:3648740Inparanoid, OMA
Rat498940Ces2hcarboxylesterase 2H10116RGD:1560889Inparanoid, OMA
Dog489769CES2carboxylesterase 29615VGNC:39153Inparanoid, OMA, EggNOG
Horse100065668CES2carboxylesterase 29796VGNC:16444Inparanoid, OMA
Cow505928CES2carboxylesterase 29913VGNC:27229Inparanoid, OMA, EggNOG
Anole lizard100565018LOC100565018liver carboxylesterase 228377Inparanoid, OMA
Zebrafish566132ces2carboxylesterase 2 (intestine, liver)7955ZDB-GENE-061013-99Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    serine protease    /    Cocaine esterase
protein    /    lipase    /    Cocaine esterase
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Lipase    /    Cocaine esterase

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      active Crohn's disease1059Expression AtlasMONDO:0005011
      acute quadriplegic myopathy1255Expression AtlasMONDO:0005336
      Becker muscular dystrophy187Expression AtlasMONDO:0010311
      colon cancer1587Expression AtlasMONDO:0021063
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170
      pancreatic ductal adenocarcinoma liver metastasis3122Expression AtlasMONDO:0005184
      ulcerative colitis2513Expression AtlasMONDO:0005101
      Cocaine-Related Disorders105CTDMONDO:0004456

      Bibliography

      1.Yan, B B, Matoney, L L and Yang, D D. 1999-09 Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. [PMID:10452915]
      2.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      3.Wiemann, S S and 23 more authors. 2001-03 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. [PMID:11230166]
      4.Chagnon, Pierre P and 8 more authors. 2002-12 A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. [PMID:12417987]
      5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      6.Saito, Susumu S and 6 more authors. 2003 Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. [PMID:12721789]
      7.Wu, Michael H MH and 5 more authors. 2003-07 Characterization of multiple promoters in the human carboxylesterase 2 gene. [PMID:12835618]
      8.Mathijssen, Ron H J RH and 7 more authors. 2003-08-15 Irinotecan pathway genotype analysis to predict pharmacokinetics. [PMID:12960109]
      9.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      10.Marsh, Sharon S and 7 more authors. 2004-10 Pharmacogenomic assessment of carboxylesterases 1 and 2. [PMID:15475243]