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THRB

DescriptionThyroid hormone receptor beta

Gene and Protein Information

Gene ID7068
Uniprot Accession IDs B3KU79 P37243 Q13986 Q3KP35 Q6WGL2 Q9UD41
Ensembl ID ENSP00000379904
Symbol ERBA2 NR1A2 THR1 GRTH PRTH THR1 ERBA2 NR1A2 THRB1 THRB2 C-ERBA-2 C-ERBA-BETA
FamilyBelongs to the nuclear hormone receptor family. NR1 subfamily.
Sequence
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp470771THRBthyroid hormone receptor beta9598VGNC:8014OMA, EggNOG
Macaque100429549THRBthyroid hormone receptor beta9544Inparanoid, OMA
Mouse21834Thrbthyroid hormone receptor beta10090MGI:98743Inparanoid, OMA, EggNOG
Rat24831Thrbthyroid hormone receptor beta10116RGD:3858Inparanoid, OMA, EggNOG
Dog403599THRBthyroid hormone receptor beta9615VGNC:47355Inparanoid, OMA, EggNOG
Horse100051615THRBthyroid hormone receptor beta9796VGNC:24090Inparanoid, OMA, EggNOG
Cow788329THRBthyroid hormone receptor beta9913VGNC:35847Inparanoid, OMA, EggNOG
Opossum100024652THRBthyroid hormone receptor beta13616Inparanoid, OMA, EggNOG
Chicken396431THRBthyroid hormone receptor beta9031CGNC:49800Inparanoid, OMA, EggNOG
Anole lizard103280334thrbthyroid hormone receptor beta28377OMA, EggNOG
Xenopus734147thrbthyroid hormone receptor, beta8364XB-GENE-6070709Inparanoid, OMA, EggNOG
Zebrafish30607thrbthyroid hormone receptor beta7955ZDB-GENE-990415-268Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    Thyroid hormone receptor beta
protein    /    receptor    /    Thyroid hormone receptor beta
protein    /    nucleic acid binding    /    Thyroid hormone receptor beta
protein    /    C4 zinc finger nuclear receptor    /    Thyroid hormone receptor beta
DTO Classes
protein    /    Nuclear receptor    /    Thyroid Hormone Receptors    /    Thyroid hormone receptor beta

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Dressel, U U and 8 more authors. 1999-05 Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. [PMID:10207062]
      2.Kim, H J HJ and 6 more authors. 1999-09 Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. [PMID:10454579]
      3.Sasaki, S S and 10 more authors. 1999-10-01 Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. [PMID:10508171]
      4.Lee, S K SK and 14 more authors. 1999-11-26 A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. [PMID:10567404]
      5.Pérez-Juste, G G, García-Silva, S S and Aranda, A A. 2000-01-14 An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells. [PMID:10625678]
      6.Menzaghi, C C and 6 more authors. 1998 T426I a new mutation in the thyroid hormone receptor beta gene in a sporadic patient with resistance to thyroid hormone and dysmorphism. Mutations in brief no. 192. Online. [PMID:10660344]
      7.Zhu, X G XG and 7 more authors. 2000-04 The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. [PMID:10713182]
      8.Dias Neto, E E and 23 more authors. 2000-03-28 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. [PMID:10737800]
      9.Yasumo, H H and 5 more authors. 2000-01-31 Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. [PMID:10786636]
      10.Puzianowska-Kuznicka, M M and 5 more authors. 2000-07-31 Expression of thyroid hormone receptors is disturbed in human renal clear cell carcinoma. [PMID:10822129]