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CHAT

DescriptionCholine O-acetyltransferase

Gene and Protein Information

Gene ID1103
Uniprot Accession IDs A2BDF4 A2BDF5 Q16488 Q9BQ23 Q9BQ35 Q9BQE1 CHOACTase
Ensembl ID ENSP00000337103
Symbol CMS6 CMS1A CMS1A2 CHOACTASE
FamilyBelongs to the carnitine/choline acetyltransferase family.
Sequence
MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMAAKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEKATRPSQGHQP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp450451CHATcholine O-acetyltransferase9598VGNC:14505OMA, EggNOG
Macaque709977CHATcholine O-acetyltransferase9544Inparanoid, OMA, EggNOG
Mouse12647Chatcholine acetyltransferase10090MGI:88392Inparanoid, OMA, EggNOG
Rat290567Chatcholine O-acetyltransferase10116RGD:1304627Inparanoid, OMA
Dog486775CHATcholine O-acetyltransferase9615VGNC:39192Inparanoid, OMA, EggNOG
Horse100062632CHATcholine O-acetyltransferase9796VGNC:16478Inparanoid, OMA, EggNOG
Cow524732CHATcholine O-acetyltransferase9913VGNC:27269Inparanoid, OMA, EggNOG
Pig396896CHATcholine O-acetyltransferase9823Inparanoid, OMA, EggNOG
OpossumCHATcholine O-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:1912]13616Inparanoid, EggNOG
Platypus100077991CHATcholine O-acetyltransferase9258Inparanoid, OMA
Chicken395314CHATcholine O-acetyltransferase9031CGNC:1633Inparanoid, OMA, EggNOG
Anole lizard100558883chatcholine O-acetyltransferase28377Inparanoid, OMA, EggNOG
Xenopuschatcholine O-acetyltransferase [Source:Xenbase;Acc:XB-GENE-984174]8364OMA, EggNOG
Zebrafish100170938chatacholine O-acetyltransferase a7955ZDB-GENE-080102-2Inparanoid, OMA, EggNOG
Fruitfly42249ChATCholine acetyltransferase7227FBgn0000303Inparanoid, OMA
S.cerevisiae854965CAT2carnitine O-acetyltransferase CAT24932S000004506Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transferase    /    acyltransferase    /    Choline O-acetyltransferase
protein    /    transferase    /    acetyltransferase    /    Choline O-acetyltransferase
DTO Classes
protein    /    Enzyme    /    Transferase    /    Acetyltransferase    /    Choline O-acetyltransferase

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Lönnerberg, P P and Ibáñez, C F CF. 1999-07 Novel, testis-specific mRNA transcripts encoding N-terminally truncated choline acetyltransferase. [PMID:10369388]
      2. and Oda, Y Y. 1999-11 Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. [PMID:10594838]
      3.Sakakibara, A A and Hattori, S S. 2000-03-03 Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. [PMID:10692442]
      4.Dobransky, T T, Davis, W L WL, Xiao, G H GH and Rylett, R J RJ. 2000-07-01 Expression, purification and characterization of recombinant human choline acetyltransferase: phosphorylation of the enzyme regulates catalytic activity. [PMID:10861222]
      5.Ohno, K K and 9 more authors. 2001-02-13 Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans. [PMID:11172068]
      6.Robert, I I and Quirin-Stricker, C C. 2001-10 A novel untranslated 'exon H' of the human choline acetyltransferase gene in placenta. [PMID:11595752]
      7.Robert, Isabelle I, Sutter, Anne A and Quirin-Stricker, Christiane C. 2002-10-15 Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta. [PMID:12393272]
      8.Mubumbila, Victor V, Sutter, Anne A, Ptok, Ursula U, Heun, Reinhard R and Quirin-Stricker, Christiane C. 2002-11-15 Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease. [PMID:12401548]
      9.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      10.Dobransky, Tomas T, Brewer, Dyanne D, Lajoie, Gilles G and Rylett, R Jane RJ. 2003-02-21 Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42. [PMID:12486117]