Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

GRM4

DescriptionMetabotropic glutamate receptor 4

Gene and Protein Information

Gene ID2914
Uniprot Accession IDs Q14833 B3KVL9 B7Z1T9 B7Z1U6 F5GXM5 Q5SZ84 Q6ZMQ2 mGluR4
Ensembl ID ENSP00000440556
Symbol GPRC1D MGLUR4 mGlu4 GPRC1D MGLUR4
FamilyBelongs to the G-protein coupled receptor 3 family.
Sequence
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp471986GRM4glutamate metabotropic receptor 49598VGNC:12786Inparanoid, OMA, EggNOG
Macaque718489GRM4glutamate metabotropic receptor 49544OMA, EggNOG
Mouse268934Grm4glutamate receptor, metabotropic 410090MGI:1351341Inparanoid, OMA
Dog481749GRM4glutamate metabotropic receptor 49615VGNC:41511Inparanoid, OMA
Horse100061879GRM4glutamate metabotropic receptor 49796VGNC:18602Inparanoid, OMA
Cow790333GRM4glutamate metabotropic receptor 49913VGNC:53975Inparanoid, OMA
Pig100152616GRM4glutamate metabotropic receptor 49823Inparanoid, OMA
Opossum100027811GRM4glutamate metabotropic receptor 413616Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    receptor    /    G-protein coupled receptor    /    Metabotropic glutamate receptor 4
DTO Classes
protein    /    G-protein coupled receptor    /    Class C metabotropic glutamate/pheromone    /    Metabotropic glutamate receptor    /    Metabotropic glutamate receptor 4

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adult high grade glioma4998Expression AtlasMONDO:0100342
      Epilepsy, Temporal Lobe23CTDMONDO:0005115
      Nerve Degeneration0CTD
      Osteosarcoma7970CTDMONDO:0009807
      osteosarcoma7970eRAMMONDO:0009807
      Bipolar Disorder535DisGeNETMONDO:0004985
      Epilepsy, Temporal Lobe23DisGeNETMONDO:0005115
      Uncinate Epilepsy0DisGeNET
      Nerve Degeneration0DisGeNET
      Osteosarcoma7970DisGeNETMONDO:0009807

      Bibliography

      1.Fu, M M and 8 more authors. 2000-07-07 p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. [PMID:10779504]
      2.Barbon, A A, Ferraboli, S S and Barlati, S S. 2000 Assignment of the human metabotropic glutamate receptor gene GRM4 to chromosome 6 band p21.3 by radiation hybrid mapping. [PMID:10828590]
      3.Ohtsuki, T T, Toru, M M and Arinami, T T. 2001-06 Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia. [PMID:11525421]
      4.Erdemir, Tuba T, Bilican, Bilada B, Oncel, Dilhan D, Goding, Colin R CR and Yavuzer, Ugur U. 2002-01-01 DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). [PMID:11801738]
      5.Collard, Charles D CD and 6 more authors. 2002-04-26 Neutrophil-derived glutamate regulates vascular endothelial barrier function. [PMID:11847215]
      6. and Enz, Ralf R. 2002-03-13 The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. [PMID:11943148]
      7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      8.Mungall, A J AJ and 170 more authors. 2003-10-23 The DNA sequence and analysis of human chromosome 6. [PMID:14574404]
      9.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      10.Iacovelli, L L and 8 more authors. 2004-05 Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). [PMID:15102938]