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KCNH2

DescriptionPotassium voltage-gated channel subfamily H member 2

Gene and Protein Information

Gene ID3757
Uniprot Accession IDs A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0
Ensembl ID ENSP00000262186
Symbol ERG ERG1 HERG ERG1 HERG LQT2 SQT1 ERG-1 H-ERG HERG1 Kv11.1
FamilyBelongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
Sequence
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463894KCNH2potassium voltage-gated channel subfamily H member 29598VGNC:8694OMA, EggNOG
Macaque714174KCNH2potassium voltage-gated channel subfamily H member 29544OMA, EggNOG
Mouse16511Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 210090MGI:1341722Inparanoid, OMA, EggNOG
Rat117018Kcnh2potassium voltage-gated channel subfamily H member 210116RGD:621414Inparanoid, OMA, EggNOG
Dog403761KCNH2potassium voltage-gated channel subfamily H member 29615VGNC:42248Inparanoid, OMA
Opossum100017968KCNH2potassium voltage-gated channel subfamily H member 213616Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Ion channel    /    Potassium channel family    /    H (Eag) subfamily    /    Kv11.1/KCNH2 sub-subfamily    /    Potassium voltage-gated channel subfamily H member 2

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

  1. amiodaroneTetrahydrouridine

    RETTclinIC

    BLOCKER pIC50: 5.00

  2. dofetilideTetrahydrouridine

    RETTclinIC

    BLOCKER pKi: 8.19

  3. guanidineTetrahydrouridine

    RETTclinIC

    BLOCKER p: 0.00

  4. sotalolTetrahydrouridine

    RETTclinIC

    BLOCKER pKi: 4.00

  5. fampridineTetrahydrouridine

    RETTclinIC

    BLOCKER pIC50: 4.05

  6. amifampridineTetrahydrouridine

    RETTclinIC

    BLOCKER p: 0.00

Associated Active Ligands

    Associated Diseases

    NameDirect Associated TargetsDisease TypeMondoid