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FCGR2B

DescriptionLow affinity immunoglobulin gamma Fc region receptor II-b

Gene and Protein Information

Gene ID2213
Uniprot Accession IDs P31994 A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1 IgG Fc receptor II-b
Ensembl ID ENSP00000351497
Symbol CD32 FCG2 IGFR2 CD32 FCG2 CD32B FCGR2 IGFR2 FCGR2C FcRII-c
Sequence
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
MacaqueFCGR2Alow affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [Source:RefSeq peptide;Acc:NP_001244231]9544OMA, EggNOG
Mouse14130Fcgr2bFc receptor, IgG, low affinity IIb10090MGI:95499OMA, EggNOG
Dog100856270LOC100856270low affinity immunoglobulin gamma Fc region receptor II9615OMA, EggNOG
Cow282229FCGR2BFc fragment of IgG receptor IIb9913OMA, EggNOG
Pig613131FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)9823OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    cell adhesion molecule    /    Low affinity immunoglobulin gamma Fc region receptor II-b
DTO Classes
protein    /    Cell adhesion    /    Low affinity immunoglobulin gamma Fc region receptor II-b

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Sondermann, P P, Huber, R R and Jacob, U U. 1999-03-01 Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. [PMID:10064577]
      2.Koncz, G G, Pecht, I I, Gergely, J J and Sármay, G G. 1999-06 Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase. [PMID:10382761]
      3.Muraille, E E, Bruhns, P P, Pesesse, X X, Daëron, M M and Erneux, C C. 2000-04-03 The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. [PMID:10789675]
      4.Pricop, L L and 6 more authors. 2001-01-01 Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. [PMID:11123333]
      5.Lyden, T W TW and 8 more authors. 2001-03-15 The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2. [PMID:11238632]
      6.Bharadwaj, D D, Mold, C C, Markham, E E and Du Clos, T W TW. 2001-06-01 Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. [PMID:11359830]
      7.Jessup, C F CF and 6 more authors. 2001-07 The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes. [PMID:11423173]
      8.Mimura, Y Y and 6 more authors. 2001-12-07 Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding. [PMID:11567028]
      9.Ding, L L and Shevach, E M EM. 2001-09 Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen. [PMID:11576217]
      10.Radaev, Sergei S and Sun, Peter P. 2002-05 Recognition of immunoglobulins by Fcgamma receptors. [PMID:11955599]