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GLP1R

DescriptionGlucagon-like peptide 1 receptor

Gene and Protein Information

Gene ID2740
Uniprot Accession IDs Q2M229 Q99669 GLP-1 receptor
Ensembl ID ENSP00000362353
Symbol GLP-1 GLP-1R GLP-1-R
FamilyBelongs to the G-protein coupled receptor 2 family.
Sequence
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp472001GLP1Rglucagon like peptide 1 receptor9598VGNC:2844OMA, EggNOG
Macaque719548GLP1Rglucagon like peptide 1 receptor9544OMA, EggNOG
Mouse14652Glp1rglucagon-like peptide 1 receptor10090MGI:99571Inparanoid, OMA, EggNOG
Rat25051Glp1rglucagon-like peptide 1 receptor10116RGD:2703Inparanoid, OMA, EggNOG
Dog481778GLP1Rglucagon like peptide 1 receptor9615VGNC:41266Inparanoid, OMA, EggNOG
Horse100065307GLP1Rglucagon like peptide 1 receptor9796VGNC:18383Inparanoid, OMA, EggNOG
Cow517420GLP1Rglucagon like peptide 1 receptor9913VGNC:29410Inparanoid, OMA, EggNOG
Pig100154059GLP1Rglucagon like peptide 1 receptor9823Inparanoid, OMA, EggNOG
Opossum100026886GLP1Rglucagon like peptide 1 receptor13616Inparanoid, OMA, EggNOG
PlatypusGLP1Rglucagon like peptide 1 receptor [Source:HGNC Symbol;Acc:HGNC:4324]9258OMA, EggNOG
Chicken428573GLP1Rglucagon like peptide 1 receptor9031CGNC:7660Inparanoid, OMA, EggNOG
Anole lizard103283040glp1rglucagon like peptide 1 receptor28377Inparanoid, OMA
XenopusGLP1Rglucagon like peptide 1 receptor [Source:HGNC Symbol;Acc:HGNC:4324]8364OMA, EggNOG

Protein Classes

DTO Classes
protein    /    G-protein coupled receptor    /    Class B secretin like    /    Glucagon receptor    /    Glucagon-like peptide 1 receptor

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      osteosarcoma7970Expression AtlasMONDO:0009807
      psoriasis6696Expression AtlasMONDO:0005083
      Diabetes Mellitus, Type 2290CTDMONDO:0005148
      Hyperplasia27CTDMONDO:0005043
      Hypertension194CTDMONDO:0005044
      Neoplasms162CTDMONDO:0004992
      Malignant Neoplasms162DisGeNETMONDO:0004992
      Hyperplasia27DisGeNETMONDO:0005043
      Hypertensive disease194DisGeNETMONDO:0005044
      Neoplasms0DisGeNET

      Bibliography

      1.Frimurer, T M TM and Bywater, R P RP. 1999-06-01 Structure of the integral membrane domain of the GLP1 receptor. [PMID:10382665]
      2.Huypens, P P, Ling, Z Z, Pipeleers, D D and Schuit, F F. 2000-08 Glucagon receptors on human islet cells contribute to glucose competence of insulin release. [PMID:10990079]
      3.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      4.Xiao, Q Q, Jeng, W W and Wheeler, M B MB. 2000-12 Characterization of glucagon-like peptide-1 receptor-binding determinants. [PMID:11116211]
      5.Bazarsuren, Ariuna A and 7 more authors. 2002-05-02 In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor. [PMID:12034449]
      6.Feldman, David S DS and 8 more authors. 2002-08-09 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. [PMID:12036966]
      7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      8.Mungall, A J AJ and 170 more authors. 2003-10-23 The DNA sequence and analysis of human chromosome 6. [PMID:14574404]
      9.Tokuyama, Yoshiharu Y and 5 more authors. 2004-10 Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. [PMID:15364163]
      10.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]